CONTRIBUTION OF CORE BODY TEMPERATURE, PRIOR WAKE TIME, AND SLEEP STAGES TO COGNITIVE THROUGHPUT PERFORMANCE DURING FORCED DESYNCHRONY

被引:37
作者
Darwent, David [1 ]
Ferguson, Sally A. [1 ]
Sargent, Charli [1 ]
Paech, Gemma M. [1 ]
Williams, Louise [1 ]
Zhou, Xuan [1 ]
Matthews, Raymond W. [1 ]
Dawson, Drew [1 ]
Kennaway, David J. [2 ]
Roach, Greg D. [1 ]
机构
[1] Univ S Australia, Ctr Sleep Res, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Dept Obstet & Gynaecol, Res Ctr Reprod Hlth, Adelaide, SA 5001, Australia
基金
澳大利亚研究理事会;
关键词
Circadian rhythms; Cognitive performance; Core body temperature; Forced desynchrony; Sleep; REM-SLEEP; CIRCADIAN PACEMAKER; DOSE-RESPONSE; DEPRIVATION; HUMANS; ALERTNESS; EEG; METAANALYSIS; RESTRICTION; WAKEFULNESS;
D O I
10.3109/07420528.2010.488621
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Shiftworkers are often required to sleep at inappropriate phases of their circadian timekeeping system, with implications for the dynamics of ultradian sleep stages. The independent effects of these changes on cognitive throughput performance are not well understood. This is because the effects of sleep on performance are usually confounded with circadian factors that cannot be controlled under normal day/night conditions. The aim of this study was to assess the contribution of prior wake, core body temperature, and sleep stages to cognitive throughput performance under conditions of forced desynchrony (FD). A total of 11 healthy young adult males resided in a sleep laboratory in which day/night zeitgebers were eliminated and ambient room temperature, lighting levels, and behavior were controlled. The protocol included 2 training days, a baseline day, and 7 x 28-h FD periods. Each FD period consisted of an 18.7-h wake period followed by a 9.3-h rest period. Sleep was assessed using standard polysomnography. Core body temperature and physical activity were assessed continuously in 1-min epochs. Cognitive throughput was measured by a 5-min serial addition and subtraction (SAS) task and a 90-s digit symbol substitution (DSS) task. These were administered in test sessions scheduled every 2.5 h across the wake periods of each FD period. On average, sleep periods had a mean (+/- standard deviation) duration of 8.5 (+/- 1.2) h in which participants obtained 7.6 (+/- 1.4) h of total sleep time. This included 4.2 (+/- 1.2) h of stage 1 and stage 2 sleep (S1-S2 sleep), 1.6 (+/- 0.6) h of slow-wave sleep (SWS), and 1.8 (+/- 0.6) h of rapid eye movement (REM) sleep. A mixed-model analysis with five covariates indicated significant fixed effects on cognitive throughput for circadian phase, prior wake time, and amount of REM sleep. Significant effects for S1-S2 sleep and SWS were not found. The results demonstrate that variations in core body temperature, time awake, and amount of REM sleep are associated with changes in cognitive throughput performance. The absence of significant effect for SWS may be attributable to the truncated range of sleep period durations sampled in this study. However, because the mean and variance for SWS were similar to REM sleep, these results suggest that cognitive throughput may be more sensitive to variations in REM sleep than SWS. (Author correspondence: david.darwent@unisa.edu.au)
引用
收藏
页码:898 / 910
页数:13
相关论文
共 35 条
[1]   Shift work and disturbed sleep/wakefulness [J].
Åkerstedt, T .
OCCUPATIONAL MEDICINE-OXFORD, 2003, 53 (02) :89-94
[2]   Experimental separation of time of day and homeostatic influences on sleep [J].
Åkerstedt, T ;
Hume, K ;
Minors, D ;
Waterhouse, J .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (04) :R1162-R1168
[3]   THE CIRCADIAN VARIATION OF EXPERIMENTALLY DISPLACED SLEEP [J].
AKERSTEDT, T ;
GILLBERG, M .
SLEEP, 1981, 4 (02) :159-169
[4]   Accounting for partial sleep deprivation and cumulative sleepiness in the Three-Process Model of alertness regulation [J].
Akerstedt, Torbjorn ;
Ingre, Michael ;
Kecklund, Goran ;
Folkard, Simon ;
Axelsson, John .
CHRONOBIOLOGY INTERNATIONAL, 2008, 25 (2-3) :309-319
[5]   REM-SLEEP DEPRIVATION DURING 5 HOURS LEADS TO AN IMMEDIATE REM-SLEEP REBOUND AND TO SUPPRESSION OF NON-REM SLEEP INTENSITY [J].
BEERSMA, DGM ;
DIJK, DJ ;
BLOK, CGH ;
EVERHARDUS, I .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 76 (02) :114-122
[6]   Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study [J].
Belenky, G ;
Wesensten, NJ ;
Thorne, DR ;
Thomas, ML ;
Sing, HC ;
Redmond, DP ;
Russo, MB ;
Balkin, TJ .
JOURNAL OF SLEEP RESEARCH, 2003, 12 (01) :1-12
[7]   REPEATED PARTIAL SLEEP-DEPRIVATION PROGRESSIVELY CHANGES THE EEG DURING SLEEP AND WAKEFULNESS [J].
BRUNNER, DP ;
DIJK, DJ ;
BORBELY, AA .
SLEEP, 1993, 16 (02) :100-113
[8]   EFFECT OF PARTIAL SLEEP-DEPRIVATION ON SLEEP STAGES AND EEG POWER SPECTRA - EVIDENCE FOR NON-REM AND REM-SLEEP HOMEOSTASIS [J].
BRUNNER, DP ;
DIJK, DJ ;
TOBLER, I ;
BORBELY, AA .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1990, 75 (06) :492-499
[9]   Intrinsic circadian period of adolescent humans measured in conditions of forced desynchrony [J].
Carskadon, MA ;
Labyak, SE ;
Acebo, C ;
Seifer, R .
NEUROSCIENCE LETTERS, 1999, 260 (02) :129-132
[10]   Stability, precision, and near-24-hour period of the human circadian pacemaker [J].
Czeisler, CA ;
Duffy, JF ;
Shanahan, TL ;
Brown, EN ;
Mitchell, JF ;
Rimmer, DW ;
Ronda, JM ;
Silva, EJ ;
Allan, JS ;
Emens, JS ;
Dijk, DJ ;
Kronauer, RE .
SCIENCE, 1999, 284 (5423) :2177-2181