Anaerobic metabolism of 1-amino-2-naphthol-based azo dyes (Sudan dyes) by human intestinal microflora

被引：85
作者：
Xu, Haiyan
Heinze, Thomas M.
Chen, Siwei
Cerniglia, Carl E.
Chen, Huizhong
机构：
[1] US FDA, Natl Ctr Toxicol Res, Div Microbiol, Jefferson, AR 72079 USA
[2] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2007年 / 73卷 / 23期
关键词：
D O I：
10.1128/AEM.01410-07
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines.
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收藏
页码：7759 / 7762
页数：4
相关论文
共 23 条
  • [11] Federal Institute for Risk Assessment, 2003, DYES SUD 1 4 FOOD
  • [12] Molecular analysis of human forearm superficial skin bacterial biota
    Gao, Zhan
    Tseng, Chi-hong
    Pei, Zhiheng
    Blaser, Martin J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (08) : 2927 - 2932
  • [13] Kulla HG, 1984, CURRENT PERSPECTIVES, P663
  • [14] Crystal structure of an aerobic FMN-dependent azoreductase (AzoA) from Enterococcus faecalis
    Liu, Zhi-Jie
    Chen, Huizhong
    Shaw, Neil
    Hopper, Sherryll L.
    Chen, Lirong
    Chen, Siwei
    Cerniglia, Carl E.
    Wang, Bi-Cheng
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 463 (01) : 68 - 77
  • [15] METABOLISM OF THE BENZIDINE-BASED AZO DYE DIRECT BLACK-38 BY HUMAN INTESTINAL MICROBIOTA
    MANNING, BW
    CERNIGLIA, CE
    FEDERLE, TW
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1985, 50 (01) : 10 - 15
  • [16] Determination of 1-phenylazo-2-naphthol (Sudan I) in chilli powder and in chilli-containing food products by GPC clean-up and HPLC with LC/MS confirmation
    Mazzetti, M
    Fascioli, R
    Mazzoncini, I
    Spinelli, G
    Morelli, I
    Bertoli, A
    [J]. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2004, 21 (10): : 935 - 941
  • [17] Reduction of pigment dispersions by Shewanella strain J18 143
    Pearce, Carolyn I.
    Guthrie, James T.
    Lloyd, Jonathan R.
    [J]. DYES AND PIGMENTS, 2008, 76 (03) : 696 - 705
  • [18] Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers
    Stiborová, M
    Martínek, V
    Rydlová, H
    Koblas, T
    Hodek, P
    [J]. CANCER LETTERS, 2005, 220 (02) : 145 - 154
  • [19] Stiborová M, 2002, CANCER RES, V62, P5678
  • [20] Stiborová M, 2006, NEUROENDOCRINOL LETT, V27, P35
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