The synthesis of novel methotrexate-like compounds

被引：4
作者：
Colak, Naki
Yildirir, Yilmaz [1 ]
Kavutcu, Mustafa
Nurlu, Nilhan
机构：
[1] Gazi Univ, Fac Sci & Art, Dept Chem, Ankara, Turkey
[2] Gazi Univ, Fac Med, Dept Med Biochem, Ankara, Turkey
来源：
MONATSHEFTE FUR CHEMIE | 2007年 / 138卷 / 12期
关键词：
methotrexate; p-aminobenzoic acid; DMAP; DCC; amino acid esters;
D O I：
10.1007/s00706-007-0716-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, H-1 NMR, and C-13 NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).
引用
收藏
页码：1283 / 1287
页数：5
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