A charge-adaptive nanosystem for prolonged enhanced in vivo antibiotic delivery

被引：71

作者：

Chu, Liping ^{[1
,2
]}

Gao, Honglin ^{[1
,2
]}

Cheng, Tangjian ^{[3
]}

Zhang, Yumin ^{[1
,2
]}

Liu, Jinjian ^{[1
,2
]}

Huang, Fan ^{[1
,2
]}

Yang, Cuihong ^{[1
,2
]}

Shi, Linqi ^{[3
]}

Liu, Jianfeng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China

[2] Peking Union Med Coll, Tianjin 300192, Peoples R China

[3] Nankai Univ, State Key Lab Med Chem Biol, Key Lab Funct Polymer Mat, Minist Educ,Inst Polymer Chem,Collaborat Innovat, Tianjin 300071, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 37期

基金：

中国国家自然科学基金;

关键词：

SURFACE-CHARGE; DRUG-DELIVERY; NANOPARTICLES; NANOMEDICINE; NANOTECHNOLOGY; NANOCARRIERS; FUTURE;

D O I：

10.1039/c6cc01269h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report on a charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotic delivery. The nanocarrier achieves acid-dependent charge conversion, thus prolonging the circulation time and enhancing antibiotic accumulation in subcutaneous inflammation models.

引用

页码：6265 / 6268

页数：4

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