An evaluation of Admedus' tissue engineering processtreated (ADAPT) bovine pericardium patch (CardioCel) for the repair of cardiac and vascular defects

被引：34
作者：
Strange, Geoff [1 ,2 ,3 ]
Brizard, Christian [4 ]
Karl, Tom R. [5 ]
Neethling, Leon [6 ,7 ]
机构：
[1] Univ Notre Dame, Fremantle, WA, Australia
[2] Royal Prince Alfred Hosp, Sydney, NSW, Australia
[3] PHSANZ, Sydney, NSW, Australia
[4] Royal Childrens Hosp, Cardiac Surg Unit, Melbourne, Vic, Australia
[5] Univ Queensland, Mater Childrens Hosp, Queensland Paediat Cardiac Serv, Brisbane, Qld 4101, Australia
[6] UWA, Sch Surg, Dept Cardiothorac Surg, Fremantle, WA, Australia
[7] Fremantle Hosp, Fremantle Heart Inst, Fremantle, WA, Australia
来源：
EXPERT REVIEW OF MEDICAL DEVICES | 2015年 / 12卷 / 02期
关键词：
ADAPT((R)); BP scaffold; BP; congenital heart disease; tissue engineering process; tissue-engineered xenograft; CONGENITAL HEART-DISEASE; SUBCUTANEOUS RAT MODEL; CALCIFICATION; BIOCOMPATIBILITY; EPIDEMIOLOGY; BIOSTABILITY;
D O I：
10.1586/17434440.2015.985651
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Tissue engineers have been seeking the Holy Grail' solution to calcification and cytotoxicity of implanted tissue for decades. Tissues with all of the desired qualities for surgical repair of congenital heart disease (CHD) are lacking. An anti-calcification tissue engineering process (ADAPT((R)) TEP) has been developed and applied to bovine pericardium (BP) tissue (CardioCel((R)), AdmedusRegen Pty Ltd, Perth, WA, Australia) to eliminate cytotoxicity, improve resistance to acute and chronic inflammation, reduce calcification and facilitate controlled tissue remodeling. Clinical data in pediatric patients, and additional pre-market authorized prescriber data demonstrate that CardioCel performs extremely well in the short term and is safe and effective for a range of congenital heart deformations. These data are supported by animal studies which have shown no more than normal physiologic levels of calcification, with good durability, biocompatibility and controlled healing.
引用
收藏
页码：135 / 141
页数：7
相关论文
共 25 条
  • [1] Persistence of perinatal mortality due to congenital malformations in resource-poor settings
    Chhabra, S.
    Darwade, R.
    Dhawde, K.
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2012, 32 (04) : 350 - 352
  • [2] Greutmann M, 2012, FUTUR CARDIOL, V8, P171, DOI [10.2217/FCA.12.6, 10.2217/fca.12.6]
  • [3] The global burden of congenital heart disease
    Hoffman, Julien Ie
    [J]. CARDIOVASCULAR JOURNAL OF AFRICA, 2013, 24 (04) : 141 - 145
  • [4] IONESCU MI, 1977, J THORAC CARDIOV SUR, V73, P31
  • [5] Current Usage and Future Directions for the Bovine Pericardial Patch
    Li, Xin
    Guo, Yuanyuan
    Ziegler, Kenneth R.
    Model, Lynn S.
    Eghbalieh, Sammy D. D.
    Brenes, Robert A.
    Kim, Susun T.
    Shu, Chang
    Dardik, Alan
    [J]. ANNALS OF VASCULAR SURGERY, 2011, 25 (04) : 561 - 568
  • [6] What does one minute of operating room time cost?
    Macario, Alex
    [J]. JOURNAL OF CLINICAL ANESTHESIA, 2010, 22 (04) : 233 - 236
  • [7] Health care resource utilization in adults with congenital heart disease
    Mackie, Andrew S.
    Pilote, Louise
    Ionescu-Ittu, Raluca
    Rahme, Elham
    Marelli, Ariane J.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (06) : 839 - 843
  • [8] Congenital heart disease in the general population - Changing prevalence and age distribution
    Marelli, Ariane J.
    Mackie, Andrew S.
    Ionescu-Ittu, Raluca
    Rahme, Elham
    Pilote, Louise
    [J]. CIRCULATION, 2007, 115 (02) : 163 - 172
  • [9] From Numbers to Guidelines
    Marelli, Ariane J.
    Gurvitz, Michelle
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 2011, 53 (04) : 239 - 246
  • [10] Epidemiology of adult congenital heart disease: demographic variations worldwide
    Mulder, B. J. M.
    [J]. NETHERLANDS HEART JOURNAL, 2012, 20 (12) : 505 - 508
123