RNA Polymerase III Advances: Structural and tRNA Functional Views

被引：74

作者：

Arimbasseri, Aneeshkumar G. ^{[1
,3
]}

Maraia, Richard J. ^{[1
,2
]}

机构：

[1] Kennedy Shriver Natl Inst Child Hlth & Human Dev, Intramural Res Program, NIH, Bethesda, MD USA

[2] US PHS, Commissioned Corps, Rockville, MD USA

[3] N Carolina State Univ, Dept Chem & Biomol Engn, Partners 2,3700, Raleigh, NC 27695 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 06期

关键词：

COMPOUND HETEROZYGOUS MUTATIONS; COPY NUMBER VARIATION; EMBRYONIC STEM-CELLS; POL-III; SACCHAROMYCES-CEREVISIAE; HYPOMYELINATING LEUKODYSTROPHY; TRANSCRIPTION TERMINATION; DIFFERENTIAL EXPRESSION; DEPENDENT TRANSCRIPTION; GENOME ORGANIZATION;

D O I：

10.1016/j.tibs.2016.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA synthesis in eukaryotes is divided among three RNA polymerases (RNAPs). RNAP III transcribes hundreds of tRNA genes and fewer additional short RNA genes. We survey recent work on transcription by RNAP III including an atomic structure, mechanisms of action, interactions with chromatin and retroposons, and a conserved link between its activity and a tRNA modification that enhances mRNA decoding. Other new work suggests important mechanistic connections to oxidative stress, autoimmunity and cancer, embryonic stem cell pluripotency, and tissue-specific developmental effects. We consider that, for some of its complex functions, variation in RNAP III activity levels lead to nonuniform changes in tRNAs that can shift the translation profiles of key codon-biased mRNAs with resultant phenotypes or disease states.

引用

页码：546 / 559

页数：14

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