Safety of intravenous β-adrenoceptor blockers for computed tomographic coronary angiography

被引：7

作者：

Clayton, Benjamin ^{[1
]}

Raju, Vikram ^{[2
]}

Roobottom, Carl ^{[2
]}

Morgan-Hughes, Gareth ^{[1
]}

机构：

[1] Derriford Hosp, Dept Cardiol, Plymouth PL6 8DH, Devon, England

[2] Derriford Hosp, Dept Radiol, Plymouth PL6 8DH, Devon, England

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2015年 / 79卷 / 03期

关键词：

adrenergic -adrenoceptor antagonists; coronary angiography; drug-related side effects and adverse reactions; metoprolol; tomography; X-ray computed; CT;

D O I：

10.1111/bcp.12516

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

AimsTo assess the safety of our clinical practice using off-label intravenous metoprolol to facilitate computed tomographic (CT) coronary angiography. MethodsA retrospective analysis of scan reports and hospital admissions data was conducted to identify adverse events occurring following CT coronary angiography in patients who had received intravenous metoprolol prior to the scan. ResultsA total of 3098 patients were included, of whom 1871 received intravenous metoprolol. Nine hundred and one patients received more than 15mg and 129 patients received metoprolol despite a resting heart rate <65 beats min(-1). There was a single adverse incident, comprising transient loss of consciousness. ConclusionsThe use of intravenous metoprolol to facilitate cardiac CT scanning appears safe. Dose limits recommended for other indications, generally in acutely unwell patients, may not need to be as stringent in this population.

引用

页码：533 / 536

页数：4

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