Brain-derived neurotrophic factor val66met polymorphism affects prefrontal energy metabolism in bipolar disorder

被引：21

作者：

Frey, Benicio N.

Walss-Bass, Consuelo

Stanley, Jeffrey A.

Nery, Fabiano G.

Matsuo, Koji

Nicoletti, Mark A.

Hatch, John P.

Bowden, Charles L.

Escamilla, Michael A.

Soares, Jair C.

机构：

[1] Univ N Carolina, Sch Med, CERT BD, Dept Psychiat, Chapel Hill, NC 27599 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Psychiat, Psychiat Genet Res Ctr, San Antonio, TX 78284 USA

[3] Univ Texas, Hlth Sci Ctr, Dept Orthodont, San Antonio, TX 78284 USA

[4] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA

[5] Univ Fed Rio Grande do Sul, ICBS, Dept Biochem, Porto Alegre, RS, Brazil

[6] Hosp Clin Porto Alegre, Bipolar Disorders Program, Porto Alegre, RS, Brazil

[7] Univ Sao Paulo, Sch Med, Dept Psychiat, Inst Psychiat, Sao Paulo, Brazil

[8] Yamaguchi Univ, Grad Sch Med, Dept Neurosci, Div Neuropsychiat, Yamaguchi, Japan

来源：

NEUROREPORT | 2007年 / 18卷 / 15期

关键词：

bipolar disorder; brain-derived neurotrophic factor; brain-derived neurotrophic factor polymorphism; dorsolateral prefrontal cortex; magnetic resonance spectroscopy;

D O I：

10.1097/WNR.0b013e3282ef7082

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor va166met polymorphism has been implicated in the pathophysiology of bipolar disorder. We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor va166met polymorphism using 'H-magnetic resonance spectroscopy. Absolute N-acetyl-aspartate, phosphocreatine+creatine (PCr+Cr), choline-containing compounds, myo-inositol, and glutamate levels were measured. Bipolar disorder met-carriers had lower PCr + Cr levels than bipolar disorder val/val patients, and bipolar disorder val/val patients had higher PCr+Cr levels than val/val healthy controls. These results indicate that bipolar disorder met-carriers have abnormal energy metabolism in the left dorsolateral prefrontal cortex.

引用

收藏

页码：1567 / 1570

页数：4

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