Effects of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer A protocol of randomized controlled trial

被引:12
作者
Liu, Chao [1 ]
Yang, Jing [1 ]
Dong, Weiwei [1 ]
Yuan, Jinyan [2 ]
机构
[1] 2 Hosp Baoding, Dept Gastroenterol, Baoding, Peoples R China
[2] Shanxi Prov Peoples Hosp Thorac Surg, Taiyuan, Shanxi, Peoples R China
关键词
complications; esophageal cancer; nutritional status; probiotics; protocol; Randomized controlled trial; SURGERY; MICROBIOTA; MORBIDITY; MORTALITY; RISK;
D O I
10.1097/MD.0000000000025138
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Gastrointestinal complications and malnutrition are common problems that affect postoperative rehabilitation and survival of patients with esophageal cancer. Evidence has shown that probiotics have a positive effect on improving gastrointestinal complications and nutritional status of patients with esophageal cancer after surgery, but there is a lack of prospective studies on this topic. We designed this prospective randomized controlled trial to evaluate the effects of probiotics on gastrointestinal complications and nutritional status in patients with postoperative esophageal cancer. Methods: This is a prospective, randomized, double-blind, placebo-controlled trial. It was approved by the Clinical Research Ethics Committee of our hospital. 192 patients will be randomly divided into probiotics group and the placebo group in a 1:1 ratio. After operation, probiotics and placebo will be given orally for 8 weeks. The indexes of nutritional status and incidence of digestive tract complications will be recorded and the data will be analyzed by SPSS 18.0 software. Discussion: This study will evaluate the effect of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer. The results of this study will provide clinical basis for the use of probiotics in postoperative treatment of esophageal cancer.
引用
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页数:4
相关论文
共 22 条
[1]   Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems [J].
Blaser, Annika Reintam ;
Malbrain, Manu L. N. G. ;
Starkopf, Joel ;
Fruhwald, Sonja ;
Jakob, Stephan M. ;
De Waele, Jan ;
Braun, Jan-Peter ;
Poeze, Martijn ;
Spies, Claudia .
INTENSIVE CARE MEDICINE, 2012, 38 (03) :384-394
[2]   Disappearing Microbiota: Helicobacter pylori Protection against Esophageal Adenocarcinoma [J].
Blaser, Martin J. .
CANCER PREVENTION RESEARCH, 2008, 1 (05) :308-311
[3]   The nutritional risk in oncology: a study of 1,453 cancer outpatients [J].
Bozzetti, Federico ;
Mariani, Luigi ;
Lo Vullo, Salvatore ;
Amerio, Maria Luisa ;
Biffi, Roberto ;
Caccialanza, Riccardo ;
Capuano, Giovanni ;
Correja, Isabel ;
Cozzaglio, Luca ;
Di Leo, Angelo ;
Di Cosmo, Leonardo ;
Finocchiaro, Concetta ;
Gavazzi, Cecilia ;
Giannoni, Antonello ;
Magnanini, Patrizia ;
Mantovani, Giovanni ;
Pellegrini, Manuela ;
Rovera, Giuseppe M. ;
Rovera, Lidia ;
Sandri, Giancarlo ;
Tinivella, Marco ;
Vigevani, Enrico .
SUPPORTIVE CARE IN CANCER, 2012, 20 (08) :1919-1928
[4]   Oral Microbiota and Risk for Esophageal Squamous Cell Carcinoma in a High-Risk Area of China [J].
Chen, Xingdong ;
Winckler, Bjorn ;
Lu, Ming ;
Cheng, Hongwei ;
Yuan, Ziyu ;
Yang, Yajun ;
Jin, Li ;
Ye, Weimin .
PLOS ONE, 2015, 10 (12)
[5]  
Dongshan Zhu., 2015, HENAN MED RES, V24, P31
[6]   Protein calorie malnutrition, nutritional intervention and personalized cancer care [J].
Gangadharan, Anju ;
Choi, Sung Eun ;
Hassan, Ahmed ;
Ayoub, Nehad M. ;
Durante, Gina ;
Balwani, Sakshi ;
Kim, Young Hee ;
Pecora, Andrew ;
Goy, Andre ;
Suh, K. Stephen .
ONCOTARGET, 2017, 8 (14) :24009-24030
[7]   Omega-3 fatty acids improve the diagnosis-related clinical outcome [J].
Heller, AR ;
Rössler, S ;
Litz, RJ ;
Stehr, SN ;
Heller, SC ;
Koch, R ;
Koch, T .
CRITICAL CARE MEDICINE, 2006, 34 (04) :972-979
[8]   Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide [J].
Hungin, A. P. S. ;
Mulligan, C. ;
Pot, B. ;
Whorwell, P. ;
Agreus, L. ;
Fracasso, P. ;
Lionis, C. ;
Mendive, J. ;
de Foy, J. -M. Philippart ;
Rubin, G. ;
Winchester, C. ;
de Wit, N. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 38 (08) :864-886
[9]   Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind study [J].
Liu, Z. ;
Qin, H. ;
Yang, Z. ;
Xia, Y. ;
Liu, W. ;
Yang, J. ;
Jiang, Y. ;
Zhang, H. ;
Yang, Z. ;
Wang, Y. ;
Zheng, Q. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 33 (01) :50-63
[10]   Nutritional Status of Patients with Cancer: A Prospective Cohort Study of 1,588 Hospitalized Patients [J].
Na, Byung-Gon ;
Han, Sung-Sik ;
Cho, Yeong-Ah ;
Wie, Gyung-Ah ;
Kim, Ji-Yeon ;
Lee, Jong-Mog ;
Lee, Seung Duk ;
Kim, Seong Hoon ;
Park, Sang-Jae .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2018, 70 (08) :1228-1236