Stem cell based therapies for spinal cord injury

被引：59
作者：
Muheremu, Aikeremujiang [1 ,2 ,3 ]
Peng, Jiang [2 ]
Ao, Qiang [3 ]
机构：
[1] Xinjiang Med Univ, Affiliated Hosp 6, Dept Spine Surg, 118 Henan West St, Urumqi, Xinjiang, Peoples R China
[2] Peoples Liberat Army, Gen Hosp, Inst Orthopaed, 28 Fuxing Rd, Beijing 100853, Peoples R China
[3] China Med Univ, Dept Tissue Engn, Shenyang North New Area, 77 Puhe Rd, Shenyang 112011, Liaoning Provin, Peoples R China
来源：
TISSUE & CELL | 2016年 / 48卷 / 04期
基金：
国家高技术研究发展计划(863计划);
关键词：
Stem cell; Transplantation; Spinal cord injury; FUNCTIONAL RECOVERY; AXONAL GROWTH; TISSUE-DAMAGE; TRANSPLANTATION; REPAIR; GENERATION; NEURONS; MODEL; SAFE; OVEREXPRESSION;
D O I：
10.1016/j.tice.2016.05.008
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Treatment of spinal cord injury has always been a challenge for clinical practitioners and scientists. The development in stem cell based therapies has brought new hopes to patients with spinal cord injuries. In the last a few decades, a variety of stem cells have been used to treat spinal cord injury in animal experiments and some clinical trials. However, there are many technical and ethical challenges to overcome before this novel therapeutic method can be widely applied in clinical practice. With further research in pluripotent stem cells and combined application of genetic and tissue engineering techniques, stem cell based therapies are bond to play increasingly important role in the management of spinal cord injuries. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：328 / 333
页数：6
相关论文
共 67 条
  • [31] Associations of ATR and CHEK1 Single Nucleotide Polymorphisms with Breast Cancer
    Lin, Wei-Yu
    Brock, Ian W.
    Connley, Dan
    Cramp, Helen
    Tucker, Rachel
    Slate, Jon
    Reed, Malcolm W. R.
    Balasubramanian, Sabapathy P.
    Cannon-Albright, Lisa A.
    Camp, Nicola J.
    Cox, Angela
    [J]. PLOS ONE, 2013, 8 (07):
  • [32] Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury
    Lu, Paul
    Kadoya, Ken
    Tuszynski, Mark H.
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2014, 27 : 103 - 109
  • [33] Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury
    Lu, Paul
    Woodruff, Grace
    Wang, Yaozhi
    Graham, Lori
    Hunt, Matt
    Wu, Di
    Boehle, Eileen
    Ahmad, Ruhel
    Poplawski, Gunnar
    Brock, John
    Goldstein, Lawrence S. B.
    Tuszynski, Mark H.
    [J]. NEURON, 2014, 83 (04) : 789 - 796
  • [34] Mackay-Sim A, 2013, METHODS MOL BIOL, V1059, P229, DOI 10.1007/978-1-62703-574-3_18
  • [35] Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
    McDonald, JW
    Liu, XZ
    Qu, Y
    Liu, S
    Mickey, SK
    Turetsky, D
    Gottlieb, DI
    Choi, DW
    [J]. NATURE MEDICINE, 1999, 5 (12) : 1410 - 1412
  • [36] Blood on the tracks:: a simple twist of fate?
    Meletis, K
    Frisén, J
    [J]. TRENDS IN NEUROSCIENCES, 2003, 26 (06) : 292 - 296
  • [37] Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury
    Nakajima, Hideaki
    Uchida, Kenzo
    Guerrero, Alexander Rodriguez
    Watanabe, Shuji
    Sugita, Daisuke
    Takeura, Naoto
    Yoshida, Ai
    Long, Guang
    Wright, Karina T.
    Johnson, William E. B.
    Baba, Hisatoshi
    [J]. JOURNAL OF NEUROTRAUMA, 2012, 29 (08) : 1614 - 1625
  • [38] Stem cell delivery by lumbar puncture as a therapeutic alternative to direct injection into injured spinal cord
    Neuhuber, Birgit
    Barshinger, Alissa L.
    Paul, Courtney
    Shumsky, Jed S.
    Mitsui, Takahiko
    Fischer, Itzhak
    [J]. JOURNAL OF NEUROSURGERY-SPINE, 2008, 9 (04) : 390 - 399
  • [39] Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury
    Nishimura, Soraya
    Yasuda, Akimasa
    Iwai, Hiroki
    Takano, Morito
    Kobayashi, Yoshiomi
    Nori, Satoshi
    Tsuji, Osahiko
    Fujiyoshi, Kanehiro
    Ebise, Hayao
    Toyama, Yoshiaki
    Okano, Hideyuki
    Nakamura, Masaya
    [J]. MOLECULAR BRAIN, 2013, 6
  • [40] Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
    Nori, Satoshi
    Okada, Yohei
    Yasuda, Akimasa
    Tsuji, Osahiko
    Takahashi, Yuichiro
    Kobayashi, Yoshiomi
    Fujiyoshi, Kanehiro
    Koike, Masato
    Uchiyama, Yasuo
    Ikeda, Eiji
    Toyama, Yoshiaki
    Yamanaka, Shinya
    Nakamura, Masaya
    Okano, Hideyuki
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (40) : 16825 - 16830
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