Stem cell based therapies for spinal cord injury

被引：59
作者：
Muheremu, Aikeremujiang [1 ,2 ,3 ]
Peng, Jiang [2 ]
Ao, Qiang [3 ]
机构：
[1] Xinjiang Med Univ, Affiliated Hosp 6, Dept Spine Surg, 118 Henan West St, Urumqi, Xinjiang, Peoples R China
[2] Peoples Liberat Army, Gen Hosp, Inst Orthopaed, 28 Fuxing Rd, Beijing 100853, Peoples R China
[3] China Med Univ, Dept Tissue Engn, Shenyang North New Area, 77 Puhe Rd, Shenyang 112011, Liaoning Provin, Peoples R China
来源：
TISSUE & CELL | 2016年 / 48卷 / 04期
基金：
国家高技术研究发展计划(863计划);
关键词：
Stem cell; Transplantation; Spinal cord injury; FUNCTIONAL RECOVERY; AXONAL GROWTH; TISSUE-DAMAGE; TRANSPLANTATION; REPAIR; GENERATION; NEURONS; MODEL; SAFE; OVEREXPRESSION;
D O I：
10.1016/j.tice.2016.05.008
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Treatment of spinal cord injury has always been a challenge for clinical practitioners and scientists. The development in stem cell based therapies has brought new hopes to patients with spinal cord injuries. In the last a few decades, a variety of stem cells have been used to treat spinal cord injury in animal experiments and some clinical trials. However, there are many technical and ethical challenges to overcome before this novel therapeutic method can be widely applied in clinical practice. With further research in pluripotent stem cells and combined application of genetic and tissue engineering techniques, stem cell based therapies are bond to play increasingly important role in the management of spinal cord injuries. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：328 / 333
页数：6
相关论文
共 67 条
  • [21] Transplantation of embryonic stem cell-derived neural stem cells for spinal cord injury in adult mice
    Kimura, H
    Yoshikawa, M
    Matsuda, R
    Toriumi, H
    Nishimura, F
    Hirabayashi, H
    Nakase, H
    Kawaguchi, S
    Ishizaka, S
    Sakaki, T
    [J]. NEUROLOGICAL RESEARCH, 2005, 27 (08) : 812 - 819
  • [22] Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions
    Kirkeby, Agnete
    Grealish, Shane
    Wolf, Daniel A.
    Nelander, Jenny
    Wood, James
    Lundblad, Martin
    Lindvall, Olle
    Parmar, Malin
    [J]. CELL REPORTS, 2012, 1 (06): : 703 - 714
  • [23] Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity
    Kobayashi, Yoshiomi
    Okada, Yohei
    Itakura, Go
    Iwai, Hiroki
    Nishimura, Soraya
    Yasuda, Akimasa
    Nori, Satoshi
    Hikishima, Keigo
    Konomi, Tsunehiko
    Fujiyoshi, Kanehiro
    Tsuji, Osahiko
    Toyama, Yoshiaki
    Yamanaka, Shinya
    Nakamura, Masaya
    Okano, Hideyuki
    [J]. PLOS ONE, 2012, 7 (12):
  • [24] Genetically modified mesenchymal stem cells (MSCs) promote axonal regeneration and prevent hypersensitivity after spinal cord injury
    Kumagai, Gentaro
    Tsoulfas, Pantelis
    Toh, Satoshi
    McNiece, Ian
    Bramlett, Helen M.
    Dietrich, W. Dalton
    [J]. EXPERIMENTAL NEUROLOGY, 2013, 248 : 369 - 380
  • [25] Emerging Repair, Regeneration, and Translational Research Advances for Spinal Cord Injury
    Kwon, Brian K.
    Sekhon, Lali H.
    Fehlings, Michael G.
    [J]. SPINE, 2010, 35 (21) : S263 - S270
  • [26] Percutaneous transplantation of human umbilical cord blood-derived multipotent stem cells in a canine model of spinal cord injury Laboratory investigation
    Lee, Jae-Hoon
    Chang, Hwa-Seok
    Kang, Eun-Hee
    Chung, Dai-Jung
    Choi, Chi-Bong
    Lee, Jong-Hwan
    Hwang, Soo-Han
    Han, Hoon
    Kim, Hwi-Yool
    [J]. JOURNAL OF NEUROSURGERY-SPINE, 2009, 11 (06) : 749 - 757
  • [27] Overexpression of Bcl-XL in Human Neural Stem Cells Promotes Graft Survival and Functional Recovery Following Transplantation in Spinal Cord Injury
    Lee, Seung I.
    Kim, Byung G.
    Hwang, Dong H.
    Kim, Hyuk M.
    Kim, Seung U.
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2009, 87 (14) : 3186 - 3197
  • [28] Li Huiying, 2010, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V24, P180
  • [29] Li J, 2007, BIOMED ENVIRON SCI, V20, P242
  • [30] Olfactory Mucosal Autografts and Rehabilitation for Chronic Traumatic Spinal Cord Injury
    Lima, Carlos
    Escada, Pedro
    Pratas-Vital, Jose
    Branco, Catarina
    Arcangeli, Carlo Alberto
    Lazzeri, Giovanna
    Santana Maia, Carlos Alberto
    Capucho, Clara
    Hasse-Ferreira, Armando
    Peduzzi, Jean D.
    [J]. NEUROREHABILITATION AND NEURAL REPAIR, 2010, 24 (01) : 10 - 22
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