Infectious tolerance: therapeutic potential

被引：44

作者：

Kendal, Adrian R. ^{[1
]}

Waldmann, Herman ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Therapeut Immunol Grp, Oxford OX1 3RE, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 05期

基金：

英国医学研究理事会;

关键词：

REGULATORY T-CELLS; GROWTH-FACTOR-BETA; OKT3; MONOCLONAL-ANTIBODY; TUMOR-NECROSIS-FACTOR; DENDRITIC CELLS; TGF-BETA; TRANSPLANTATION TOLERANCE; PERIPHERAL TOLERANCE; PHASE-III; IN-VITRO;

D O I：

10.1016/j.coi.2010.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infectious tolerance describes an in vivo process in which tolerance is passed on from one population of lymphocytes to another In this way, short-term therapy aimed at generating infectious tolerance has the potential to achieve long term, self-perpetuating immune homeostasis in a clinical setting In recent years a number of differing strategies have successfully achieved tolerance in vivo These include harnessing regulatory T cells and tolerogenic antigen presenting cells promoting tolerogenic interactions or inhibiting activation of effector cells Many of these are just beginning to face the harsh realities of the therapeutics industry

引用

页码：560 / 565

页数：6

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