Genomewide Analysis of Divergence of Antibiotic Resistance Determinants in Closely Related Isolates of Acinetobacter baumannii

被引：91
作者：
Adams, Mark D. [1 ,5 ]
Chan, E. Ricky [1 ]
Molyneaux, Neil D. [1 ]
Bonomo, Robert A. [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Pharmacol & Mol Biol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Dept Microbiol, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Ctr Prote & Bioinformat, Cleveland, OH 44106 USA
[6] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Cleveland, OH 44106 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期
关键词：
INTENSIVE-CARE-UNIT; MULTIDRUG-RESISTANCE; BLA(OXA-58) GENE; MEDICAL-CENTER; EVOLUTION; SEQUENCE; STRAINS; PLASMID; ALGORITHMS; DIVERSITY;
D O I：
10.1128/AAC.00057-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed differences in antimicrobial susceptibility. Resistance genes associated with insertion sequences, plasmids, and a chromosomal resistance gene island all showed variability. The highly dynamic resistance gene repertoire suggests rapid evolution of drug resistance.
引用
收藏
页码：3569 / 3577
页数：9
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