Genomewide Analysis of Divergence of Antibiotic Resistance Determinants in Closely Related Isolates of Acinetobacter baumannii

被引：91
|
作者：
Adams, Mark D. [1 ,5 ]
Chan, E. Ricky [1 ]
Molyneaux, Neil D. [1 ]
Bonomo, Robert A. [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Pharmacol & Mol Biol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Dept Microbiol, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Ctr Prote & Bioinformat, Cleveland, OH 44106 USA
[6] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Cleveland, OH 44106 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期
关键词：
INTENSIVE-CARE-UNIT; MULTIDRUG-RESISTANCE; BLA(OXA-58) GENE; MEDICAL-CENTER; EVOLUTION; SEQUENCE; STRAINS; PLASMID; ALGORITHMS; DIVERSITY;
D O I：
10.1128/AAC.00057-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Multidrug resistance has emerged as a significant concern with infections caused by Acinetobacter baumannii. Ample evidence supports the involvement of mobile genetic elements in the transfer of antibiotic resistance genes, but the extent of variability and the rate of genetic change associated with the acquisition of antibiotic resistance have not been studied in detail. Whole-genome sequence analysis of six closely related clinical isolates of A. baumannii, including four from the same hospital, revealed extensive divergence of the resistance genotype that correlated with observed differences in antimicrobial susceptibility. Resistance genes associated with insertion sequences, plasmids, and a chromosomal resistance gene island all showed variability. The highly dynamic resistance gene repertoire suggests rapid evolution of drug resistance.
引用
收藏
页码：3569 / 3577
页数：9
相关论文
共 50 条
  • [21] Investigating the Link Between Biofilm Formation and Antibiotic Resistance in Clinical Isolates of Acinetobacter baumannii
    Javadi, Kasra
    Ghaemian, Poorya
    Baziboron, Mana
    Pournajaf, Abazar
    INTERNATIONAL JOURNAL OF MICROBIOLOGY, 2025, 2025 (01)
  • [22] Antimicrobial Resistance Determinants in Acinetobacter baumannii Isolates Taken from Military Treatment Facilities
    Taitt, Chris Rowe
    Leski, Tomasz A.
    Stockelman, Michael G.
    Craft, David W.
    Zurawski, Daniel V.
    Kirkup, Benjamin C.
    Vora, Gary J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (02) : 767 - 781
  • [23] Antibiotic Resistance Mechanisms and Their Transmission in Acinetobacter baumannii
    McCarthy, Ronan R.
    Larrouy-Maumus, Gerald J.
    Tan, Mei Gei C. Meiqi
    Wareham, David W.
    MICROBIAL PATHOGENESIS: INFECTION AND IMMUNITY, 2ND EDITION, 2021, 1313 : 135 - 153
  • [24] Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance
    Abdi, Seyyed Naser
    Ghotaslou, Reza
    Ganbarov, Khudaverdi
    Mobed, Ahmad
    Tanomand, Asghar
    Yousefi, Mehdi
    Asgharzadeh, Mohammad
    Kafil, Hossein Samadi
    INFECTION AND DRUG RESISTANCE, 2020, 13 : 423 - 434
  • [25] Genomic analysis of antibiotic resistance for Acinetobacter baumannii in a critical care center
    Murata, Kensuke
    Inoue, Yoshiaki
    Kaiho, Mayuko
    Nakazawa, Takeshi
    Sasaki, Shin-ichi
    Miyake, Kazunori
    Matsuda, Shigeru
    Tanaka, Hiroshi
    ACUTE MEDICINE & SURGERY, 2020, 7 (01):
  • [26] Correlation of biofilm formation and antibiotic resistance among clinical and soil isolates of Acinetobacter baumannii in Iraq
    Hassan, Pakhshan A.
    Khider, Adel K.
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2020, 67 (03) : 161 - 170
  • [27] The Relationship Between Antibiotic Resistance Phenotypes and Biofilm Formation Capacity in Clinical Isolates of Acinetobacter baumannii
    Rahimi, Sara
    Farshadzadeh, Zahra
    Taheri, Behrouz
    Mohammadi, Mohsen
    Haghighi, Mohammad-Ali
    Bahador, Abbas
    JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2018, 11 (08)
  • [28] Biofilm formation, antibiotic-resistance and clonal relatedness among clinical isolates of Acinetobacter baumannii
    Aramli, Nima
    Safarkar, Roya
    Shiralipour, Aref
    Sadeghi, Zahra
    MICROBIAL PATHOGENESIS, 2024, 195
  • [29] Detection of the plasmid-mediated quinolone resistance determinants in clinical isolates of Acinetobacter baumannii in China
    Yang, Haifei
    Hu, Lifen
    Liu, Yanyan
    Ye, Ying
    Li, Jiabin
    JOURNAL OF CHEMOTHERAPY, 2016, 28 (05) : 443 - 445
  • [30] Correlation between antibiotic resistance and serum resistance in Acinetobacter baumannii
    Guo, Tingting
    Shan, Cailong
    Li, Jinyue
    Feng, Huanhuan
    Li, Mengying
    Zheng, Wenhao
    Jiang, Qianqian
    Chen, Jiahao
    Jiao, Hongmei
    Li, Guocai
    Liu, Wenjuan
    Bao, Guangyu
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (08): : 9804 - 9814
12345