An efficient synthesis of nilotinib (AMN107)

被引：42
作者：
Huang, Wei-Sheng [1 ]
Shakespeare, William C. [1 ]
机构：
[1] ARIAD Pharmaceut, Cambridge, MA 02139 USA
来源：
SYNTHESIS-STUTTGART | 2007年 / 14期
关键词：
AMN107; Abl kinase inhibitor; Cu-catalyzed N-arylation; Pd-catalyzed N-arylation; atom economy;
D O I：
10.1055/s-2007-983754
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise synthesis of AMN 107, a compound currently undergoing several phase II/III clinical trials for chronic myelogenous leukemia is described. The new procedure reduces the number of synthetic steps from eight to four, with an overall yield of 65%.
引用
收藏
页码：2121 / 2124
页数：4
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