Palladium(II)-Catalyzed N-Carbonylative Cross-Coupling Reaction of Sulfoximines with Aryl, Heteroaryl, and Alkenyl Halides Using Tungsten Hexacarbonyl as Carbon Monoxide Source

被引：6

作者：

Han, Sang Hoon ^{[1
]}

Lee, Kyungsup ^{[1
]}

Noh, Hee Chan ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

N-Acylation; Carbonylative Cross-coupling reaction; Palladium; Sulfoximine; Tungstene hexacarbonyl; C-H BONDS; CATALYZED AROYLATION; DOUBLE ANNULATION; ALPHA-ARYLATION; PALLADIUM; ACYLATION; ARENES; SULFILIMINES; METHYLARENES; SULFOXIDES;

D O I：

10.1002/ajoc.202100388

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium(II)-catalyzed N-acylation was demonstrated through the reaction of N-H sulfoximines with a variety of aryl, heteroaryl, and aryl halides using W(CO)(6) as a source of carbon monoxide, affording N-acylated sulfoximines in good to excellent yields. Moreover, alkenyl bromides underwent palladium(II)-catalyzed N-acylation reactions with N-H sulfoximines, leading to the formation of N-cinnamoyl sulfoximines. This method has the advantages of a broad substrate scope, high functional group tolerance, simple operation, and chemoselectivity between chloride and bromide.

引用

页码：2397 / 2405

页数：9

共 100 条

[11] Synthesis of phosphorylated sulfoximines and sulfinamides and their application as ligands in asymmetric metal catalysis [J].