Bioactive Diphenyl Ether Derivatives from a Gorgonian-Derived Fungus Talaromyces sp.

被引：29

作者：

Chen, Min ^{[1
]}

Han, Lei ^{[1
]}

Shao, Chang-Lun ^{[1
]}

She, Zhi-Gang ^{[2
]}

Wang, Chang-Yun ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2015年 / 12卷 / 03期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Fungi; Talaromyces; Diphenyl ether derivatives; Talaromycins A - C; Cytotoxic activity; Antifouling activity; ASPERGILLUS SP FUNGUS; PENICILLIUM SP;

D O I：

10.1002/cbdv.201400267

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new diphenyl ether derivatives, talaromycins A-C (1-3, resp.), together with six known analogs, 4-9, were isolated from a gorgonian-derived fungus, Talaromyces sp. The structures of the new compounds were determined by analysis of extensive NMR spectroscopic data. All of the isolated metabolites, 1-9, were evaluated for their cytotoxic and antifouling activities. Compound 4 exhibited pronounced cytotoxicity against the tested human cell lines with the IC50 values ranging from 4.3 to 9.8M. Compounds 3, 5, 8, and 9 showed potent antifouling activities against the larval settlement of the barnacle Balanus amphitrite with the EC50 values ranging from 2.2 to 4.8g/ml.

引用

页码：443 / 450

页数：8

共 14 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2]

Blunt JW, 2013, NAT PROD REP, V30, P237, DOI [10.1039/d0np00089b, 10.1039/c2np20112g]

[3] Lumazine Peptides Penilumamides B-D and the Cyclic Pentapeptide Asperpeptide A from a Gorgonian-Derived Aspergillus sp Fungus [J].

Chen, Min ;

Shao, Chang-Lun ;

Fu, Xiu-Mei ;

Kong, Chui-Jian ;

She, Zhi-Gang ;

Wang, Chang-Yun .

JOURNAL OF NATURAL PRODUCTS, 2014, 77 (07) :1601-1606

[4] Bioactive Indole Alkaloids and Phenyl Ether Derivatives from a Marine-Derived Aspergillus sp Fungus [J].

Chen, Min ;

Shao, Chang-Lun ;

Fu, Xiu-Mei ;

Xu, Ru-Fang ;

Zheng, Juan-Juan ;

Zhao, Dong-Lin ;

She, Zhi-Gang ;

Wang, Chang-Yun .

JOURNAL OF NATURAL PRODUCTS, 2013, 76 (04) :547-553

[5] Antifouling and Fungicidal Resorcylic Acid Lactones from the Sea Anemone-Derived Fungus Cochliobolus lunatus [J].

Liu, Qing-Ai ;

Shao, Chang-Lun ;

Gu, Yu-Cheng ;

Blum, Mathias ;

Gan, Li-She ;

Wang, Kai-Ling ;

Chen, Min ;

Wang, Chang-Yun .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (14) :3183-3191

[6] PURPACTINS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY PENICILLIUM-PURPUROGENUM .2. STRUCTURE ELUCIDATION OF PURPACTIN-A, PURPACTIN-B AND PURPACTIN-C [J].

NISHIDA, H ;

TOMODA, H ;

CAO, J ;

OKUDA, S ;

OMURA, S .

JOURNAL OF ANTIBIOTICS, 1991, 44 (02) :144-157

[7] Tenellic acids A-D:: New bioactive diphenyl ether derivatives from the aquatic fungus Dendrospora tenella [J].

Oh, H ;

Kwon, TO ;

Gloer, JB ;

Marvanová, L ;

Shearer, CA .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (04) :580-583

[8] POTENT, NONPEPTIDIC OXYTOCIN RECEPTOR ANTAGONISTS FROM A NATURAL SOURCE [J].

SALITURO, GM ;

PETTIBONE, DJ ;

CLINESCHMIDT, BV ;

WILLIAMSON, JM ;

ZINK, DL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (02) :337-340

[9]

SASSA T, 1974, TETRAHEDRON LETT, P3941

[10] Potent Antifouling Resorcylic Acid Lactones from the Gorgonian-Derived Fungus Cochliobolus lunatus [J].

Shao, Chang-Lun ;

Wu, Hui-Xian ;

Wang, Chang-Yun ;

Liu, Qing-Ai ;

Xu, Ying ;

Wei, Mei-Yan ;

Qian, Pei-Yuan ;

Gu, Yu-Cheng ;

Zheng, Cai-Juan ;

She, Zhi-Gang ;

Lin, Yong-Cheng .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04) :629-633

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