Parkinson's disease: Is there a strong environmental contribution?

被引：4
|
作者：
Elbaz, A. [1 ,2 ]
Moisan, F. [1 ,2 ]
机构：
[1] Hop La Pitie Salpetriere, INSERM, U708, Serv Neuroepidemiol, F-75651 Paris 13, France
[2] Univ Paris 06, UPMC, UMR S 708, F-75005 Paris, France
来源：
REVUE NEUROLOGIQUE | 2010年 / 166卷 / 10期
关键词：
Parkinson's disease; Epidemiology; Environment; PHASE-I METABOLISM; PESTICIDE EXPOSURE; OLMSTED COUNTY; MONOAMINE-OXIDASE; CIGARETTE-SMOKING; PUBLIC-HEALTH; XENOBIOTICS I; RISK-FACTORS; PREVALENCE; POPULATION;
D O I：
10.1016/j.neurol.2010.07.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is the most common cause of the parkinsonian syndromes and the most frequent neurodegenerative disease after Alzheimer's disease Only a minority of PD cases is due to a single factor, in particular a genetic mutation. In the large majority of cases, it is considered that PD is a complex or multifactorial disease that results from the effect of multiple risk or protective factors, either genetic or environmental, and, possibly, from their interaction. Epidemiological studies, through a variety of approaches, have brought important evidence in favour of the contribution of environmental factors to the etiology of PD In this review, we will present current evidence by focusing on specific illustrative examples (C) 2010 Elsevier Masson SAS. All rights reserved
引用
收藏
页码：757 / 763
页数：7
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