Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation

被引：67

作者：

Mohty, Mohamad ^{[1
]}

Labopin, Myriam ^{[2
,3
]}

Tabrizzi, Reza ^{[4
]}

Theorin, Niklas ^{[5
]}

Fauser, Axel A. ^{[6
]}

Rambaldi, Alessandro ^{[7
]}

Maertens, Johan ^{[8
]}

Slavin, Shimon ^{[9
]}

Majolino, Ignazio ^{[10
]}

Nagler, Arnon ^{[11
]}

Blaise, Didier ^{[12
]}

Rocha, Vanderson ^{[2
,3
,13
]}

机构：

[1] Univ Nantes, CHU Hotel Dieu, Serv Hematol Clin, Pl Alexis Ricordeau, F-44093 Nantes, France

[2] Hop St Antoine, AP HP, European Grp Blood & Marrow Transplantat EBMT, Acute Leukemia Working Party, Paris, France

[3] Univ Paris 06, Pierre & Marie Curie, Paris, France

[4] CHU Bordeaux, Hop Haut Leveque, Pessac, France

[5] Univ Hosp, Dept Hematol, Linkoping, Sweden

[6] Klin Knochenmarktransplantat & Haematol Onkol, Idar Oberstein, Germany

[7] Osped Bergamo, Div Ematol, Bergamo, Italy

[8] Univ Hosp Gasthuisberg, Dept Hematol, Leuven, Belgium

[9] Hadassah Univ Hosp, Dept Bone Marrow Transplantat, Jerusalem, Israel

[10] Osped S Camillo Forlanini, Dept Hematol & BMT, Rome, Italy

[11] Tel Aviv Univ, Chaim Sheba Med Ctr, Tel Hashomer, Israel

[12] Inst Paoli Calmettes, Unite Transplantat & Therapie Cellulaire, Marseille, France

[13] Hop St Louis, AP HP, Dept Hematol, Paris, France

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 02期

关键词：

allogeneic SCT; acute lymphoblastic leukemia;

D O I：

10.3324/haematol.11960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52 +/- 9%; 42 +/- 10%; and 18 +/- 7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.

引用

页码：303 / 306

页数：4

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