Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation

被引：67

作者：

Mohty, Mohamad ^{[1
]}

Labopin, Myriam ^{[2
,3
]}

Tabrizzi, Reza ^{[4
]}

Theorin, Niklas ^{[5
]}

Fauser, Axel A. ^{[6
]}

Rambaldi, Alessandro ^{[7
]}

Maertens, Johan ^{[8
]}

Slavin, Shimon ^{[9
]}

Majolino, Ignazio ^{[10
]}

Nagler, Arnon ^{[11
]}

Blaise, Didier ^{[12
]}

Rocha, Vanderson ^{[2
,3
,13
]}

机构：

[1] Univ Nantes, CHU Hotel Dieu, Serv Hematol Clin, Pl Alexis Ricordeau, F-44093 Nantes, France

[2] Hop St Antoine, AP HP, European Grp Blood & Marrow Transplantat EBMT, Acute Leukemia Working Party, Paris, France

[3] Univ Paris 06, Pierre & Marie Curie, Paris, France

[4] CHU Bordeaux, Hop Haut Leveque, Pessac, France

[5] Univ Hosp, Dept Hematol, Linkoping, Sweden

[6] Klin Knochenmarktransplantat & Haematol Onkol, Idar Oberstein, Germany

[7] Osped Bergamo, Div Ematol, Bergamo, Italy

[8] Univ Hosp Gasthuisberg, Dept Hematol, Leuven, Belgium

[9] Hadassah Univ Hosp, Dept Bone Marrow Transplantat, Jerusalem, Israel

[10] Osped S Camillo Forlanini, Dept Hematol & BMT, Rome, Italy

[11] Tel Aviv Univ, Chaim Sheba Med Ctr, Tel Hashomer, Israel

[12] Inst Paoli Calmettes, Unite Transplantat & Therapie Cellulaire, Marseille, France

[13] Hop St Louis, AP HP, Dept Hematol, Paris, France

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 02期

关键词：

allogeneic SCT; acute lymphoblastic leukemia;

D O I：

10.3324/haematol.11960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52 +/- 9%; 42 +/- 10%; and 18 +/- 7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.

引用

页码：303 / 306

页数：4

共 50 条

[1] Allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning in acute lymphoblastic leukemia:: a feasibility study
Martino, R
Giralt, S
Caballero, MD
Mackinnon, S
Corradini, P
Fernández-Avilés, F
San Miguel, J
Sierra, J
HAEMATOLOGICA, 2003, 88 (05) : 555 - 560
[2] Reduced-intensity stem-cell transplantation for adult acute lymphoblastic leukemia: a retrospective study of 33 patients
T Hamaki
M Kami
Y Kanda
K Yuji
Y Inamoto
Y Kishi
K Nakai
I Nakayama
N Murashige
Y Abe
Y Ueda
M Hino
T Inoue
H Ago
M Hidaka
T Hayashi
T Yamane
N Uoshima
S Miyakoshi
S Taniguchi
Bone Marrow Transplantation, 2005, 35 : 549 - 556
[3] Reduced-intensity stem-cell transplantation for adult acute lymphoblastic leukemia: a retrospective study of 33 patients
Hamaki, T
Kami, M
Kanda, Y
Yuji, K
Inamoto, Y
Kishi, Y
Nakai, K
Nakayama, I
Murashige, N
Abe, Y
Ueda, Y
Hino, M
Inoue, T
Ago, H
Hidaka, M
Hayashi, T
Yamane, T
Uoshima, N
Miyakoshi, S
Taniguchi, S
BONE MARROW TRANSPLANTATION, 2005, 35 (06) : 549 - 556
[4] Reduced-Intensity Conditioning followed by Peripheral Blood Stem Cell Transplantation for Adult Patients with High-Risk Acute Lymphoblastic Leukemia
Stein, Anthony S.
Palmer, Joycelynne M.
O'Donnell, Margaret R.
Kogut, Neil M.
Spielberger, Ricardo T.
Slovak, Marilyn L.
Tsai, Ni-Chun
Senitzer, David
Snyder, David S.
Thomas, Sandra H.
Forman, Stephen J.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (11) : 1407 - 1414
[5] The role of allogeneic stem cell transplantation for adult acute lymphoblastic leukemia
Paulson, K.
Szwajcer, D.
Seftel, M. D.
TRANSFUSION AND APHERESIS SCIENCE, 2011, 44 (02) : 197 - 203
[6] Role of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia
Lussana, Federico
Rambaldi, Alessandro
MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2014, 6 (01)
[7] Reduced intensity stem cell transplantation for advanced soft tissue sarcomas in adults: a retrospective analysis of the European Group for Blood and Marrow Transplantation
Secondino, Simona
Carrabba, Matteo G.
Pedrazzoli, Paolo
Castagna, Luca
Spina, Francesco
Grosso, Federica
Bertuzzi, Alexia
Bay, Jacques-Olivier
Siena, Salvatore
Corradini, Paolo
Niederwieser, Dietger
Demirer, Taner
HAEMATOLOGICA, 2007, 92 (03) : 418 - 420
[8] Allogeneic Hematopoietic Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia
Marks, David I.
Alonso, Laura
Radia, Rohini
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2014, 28 (06) : 995 - +
[9] Allogeneic Haematopoietic Stem Cell Transplantation in Patients with Acute Lymphoblastic Leukemia
Vaca, Mayra
Maria Velez, Ana
Lisa Basquiera, Ana
Arbelbide, Jorge
Agustina Perusini, Maria
Bendek, Georgina
Berro, Mariano
Milovic, Vera
Yantorno, Sebastian
Cerutti, Amalia
Cattaneo, Maximiliano
Bordone, Javier
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 : S199 - S199
[10] Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Nagler, Arnon
Labopin, Myriam
Houhou, Mohamed
Aljurf, Mahmoud
Mousavi, Ashrafsadat
Hamladji, Rose-Marie
Al Zahrani, Mohsen
Bondarenko, Sergey
Arat, Mutlu
Angelucci, Emanuele
Koc, Yener
Gulbas, Zafer
Sica, Simona
Bourhis, Jean Henri
Canaani, Jonathan
Brissot, Eolia
Giebel, Sebastian
Mohty, Mohamad
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)

← 1 2 3 4 5 →