Stereoselective synthesis of fluorinated aminoglycosyl phosphonates

被引：17
|
作者：
Bouwman, Sanne
Orru, Romano V. A.
Ruijter, Eelco [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 05期
关键词：
C-GLYCOSYLPHOSPHONATES; REAGENT SYSTEM; 2-NITROGLYCALS; BIOSYNTHESIS; GLYCALS; ANALOGS;
D O I：
10.1039/c4ob02317j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the conjugate addition of lithiated difluoromethane-phosphonates to a diverse range of nitroglycals as a convenient method for the highly stereoselective synthesis of fluorinated aminoglycosyl phosphonates. Our approach provides opportunities to produce hydrolytically stable mimics of biologically important aminoglycosyl phosphates.
引用
收藏
页码：1317 / 1321
页数：5
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