Asthma from immune pathogenesis to precision medicine

被引：41
作者：
Khalaf, Kareem [1 ]
Paoletti, Giovanni [1 ,2 ]
Puggioni, Francesca [1 ,2 ]
Racca, Francesca [1 ]
De Luca, Fabrizio [1 ]
Giorgis, Veronica [1 ]
Canonica, Giorgio Walter [1 ,2 ]
Heffler, Enrico [1 ,2 ]
机构：
[1] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy
[2] IRCCS, Personalized Med Asthma & Allergy Humanitas Clin, Rozzano, MI, Italy
来源：
SEMINARS IN IMMUNOLOGY | 2019年 / 46卷
关键词：
Asthma; Precision medicine; Innate immunity; Adaptive immunity; Phenotypes; Endotypes; INNATE LYMPHOID-CELLS; EOSINOPHILIC ASTHMA; AIRWAY INFLAMMATION; PERIPHERAL-BLOOD; DOUBLE-BLIND; MAST-CELLS; EXPRESSION; EFFICACY; RECEPTOR; CYTOKINES;
D O I：
10.1016/j.smim.2019.101294
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Asthma is characterized by multiple immunological mechanisms (endotypes) determining variable clinical presentations (phenotypes). The identification of endotypic mechanisms is crucial to better characterize patients and to identify tailored therapeutic approaches with novel biological agents targeting specific immunological pathways. This review focused on summarizing the major immunological mechanisms involved in the pathogenesis of asthma, as well as on discussing the emergence of phenotypic features of the disease. Novel biological agents and other drugs targeting specific endotypes are discussed, as their use represent a precision medicine approach to the disease that is nowadays mandatory particularly for treating more severe patients.
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页数：8
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