Targeting TNF: a therapeutic strategy for Alzheimer's disease

被引：101

作者：

Cheng, Xin ^{[1
]}

Shen, Yong ^{[1
,2
,3
]}

Li, Rena ^{[4
,5
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurol, State Key Lab Med Neurobiol, Shanghai 200040, Peoples R China

[2] Roskamp Inst, Ctr Adv Therapeut Strategies Brain Disorders, Sarasota, FL 34243 USA

[3] Univ Sci & Technol China, Sch Life Sci, Neurodegenerat Dis Res Ctr, Hefei 230027, Anhui, Peoples R China

[4] Roskamp Inst, Ctr Hormone Adv Sci & Educ, Sarasota, FL 34243 USA

[5] Capital Med Univ, Beijing Anding Hosp, Beijing Inst Brain Disorders, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2014年 / 19卷 / 11期

关键词：

TUMOR-NECROSIS-FACTOR; ANTIINFLAMMATORY PREVENTION TRIAL; TYPE-1 DIABETES MAPS; PERISPINAL ETANERCEPT; FACTOR-ALPHA; COGNITIVE IMPROVEMENT; RHEUMATOID-ARTHRITIS; MEMORY DEFICITS; BETA GENERATION; FACTOR RECEPTOR;

D O I：

10.1016/j.drudis.2014.06.029

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor necrosis factor (TNF), a ligand cytokine, is involved in systemic inflammation. Apart from the well-known pharmacological effects of TNF inhibitors on autoimmune disorders, interest in the effects of TNF in neurodegenerative disorders such as Alzheimer disease (AD) is increasing. TNF and its type 1 receptor (TNFRI) are not only involved in AD-related brain neuroinflammation, but also contribute to amyloidogenesis via beta-secretase regulation, suggesting TNF as a promising candidate for future AD therapy. Although the potential adverse effects of TNF-based AD therapies have been of concerns, here we summarize recent discoveries relating to TNF and TNFRI-mediated signal transduction as potential therapeutic targets in AD pathology and clinical investigations.

引用

收藏

页码：1822 / 1827

页数：6

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