Homocysteine and Non-Cardiac Vascular Disease

被引：39

作者：

Katsiki, Niki ^{[1
]}

Perez-Martinez, Pablo ^{[2
,3
]}

Mikhailidis, Dimitri P. ^{[4
]}

机构：

[1] Univ Thessaloniki, Propedeut Dept Internal Med 2, Sch Med, Hippocrat Hosp, Thessaloniki, Greece

[2] Univ Cordoba, Dept Internal Med, Lipid & Atherosclerosis Unit, IMIBIC,Reina Sofia Univ Hosp, Cordoba, Spain

[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain

[4] Univ Coll London UCL, Dept Clin Biochem, Univ Coll London Med Sch, Royal Free Hosp Campus, London, England

来源：

CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 22期

关键词：

Homocysteine; stroke; peripheral artery disease; carotid artery disease; chronic kidney disease; erectile dysfunction; vitamin B; ABDOMINAL AORTIC-ANEURYSM; PERIPHERAL ARTERIAL-DISEASE; FOLIC-ACID SUPPLEMENTATION; INTIMA-MEDIA THICKNESS; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; ELEVATED SERUM HOMOCYSTEINE; RENAL-FUNCTION DECLINE; ACUTE ISCHEMIC-STROKE; ALL-CAUSE MORTALITY;

D O I：

10.2174/1381612823666170317124913

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Elevated homocysteine (Hcy) levels are predictors of cardiovascular disease (CVD). Hyperhomocysteinemia has also been associated with total and CVD mortality. However, whether Hcy is just a marker or plays a causal role in CVD remains to be elucidated. In this narrative review, we discuss the associations between Hcy and non-cardiac vascular diseases, namely stroke, peripheral artery disease (PAD), carotid artery disease, chronic kidney disease (CKD), atherosclerotic renal artery stenosis (ARAS), abdominal aortic aneurysm (AAA) and erectile dysfunction (ED). The effects of several drugs on Hcy levels are also considered. Folic acid, vitamin B6 and B12 supplementation can significantly decrease circulating Hcy concentrations but their effects on CVD risk reduction are conflicting. No current guidelines recommend the routine screening of Hcy levels in patients with non-cardiac vascular diseases. Therefore, further research is needed to elucidate the use of Hcy in the clinical practice.

引用

页码：3224 / 3232

页数：9

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