Reactive oxygen species are the intermediates that are formed during the normal metabolic process which are effectively neutralized by the antioxidant system of the body. Any imbalance in this neutralization process causes oxidative stress which has been implicated as one of the cause in diseases such as Alzheimer's disease, cardiovascular disorders, cancer etc. Research has enabled the use of antioxidants as therapeutic agents in the treatment of various diseases. Literature also puts forth the negative effects of using antioxidants in the treatment of diseases. This review is a compilation of both the beneficial and detrimental effects of use of antioxidants in the treatment of diseases such as cancer, cardiovascular diseases, diabetes and oral diseases.
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Univ Tehran Med Sci, Fac Pharm, Med Plants Res Ctr, Tehran 1417614411, IranUniv Tehran Med Sci, Fac Pharm, Med Plants Res Ctr, Tehran 1417614411, Iran
Saeidnia, Soodabeh
Abdollahi, Mohammad
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Univ Tehran Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tehran 1417614411, Iran
Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 1417614411, IranUniv Tehran Med Sci, Fac Pharm, Med Plants Res Ctr, Tehran 1417614411, Iran
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SGUL, Cardiovasc Biol Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, EnglandSGUL, Cardiovasc Biol Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, England
Thomson, M. J.
Frenneaux, M. P.
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Univ Birmingham, Div Med Sci, Birmingham, W Midlands, EnglandSGUL, Cardiovasc Biol Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, England
Frenneaux, M. P.
Kaski, J. C.
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SGUL, Cardiovasc Biol Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, EnglandSGUL, Cardiovasc Biol Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, England