Lithium, a potential protective drug in Alzheimer's disease

被引：36

作者：

Engel, T. ^{[1
]}

Goni-Oliver, R. ^{[1
]}

de Barreda, E. Gomez ^{[1
]}

Lucas, J. J. ^{[1
]}

Hernandez, F. ^{[1
]}

Avila, J. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, ES-28049 Madrid, Spain

来源：

NEURODEGENERATIVE DISEASES | 2008年 / 5卷 / 3-4期

关键词：

Alzheimer's disease; tau phosphorylation; glycogen synthase kinase 3; lithium;

D O I：

10.1159/000113715

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease is characterized by the presence of two histopathological aberrant structures, the senile plaques and the neurofibrillary tangles. The main component of these tangles is the cytoskeletal protein tau in hyperphosphorylated form. Since a main tau kinase is glycogen synthase kinase 3 (GSK-3), the use of specific GSK-3 inhibitors, like lithium, could be a potential therapy in Alzheimer's disease. In this short article, we have done a review on tau phosphorylation in Alzheimer's disease and other tauopathies, and on the inhibition of kinases like GSK-3, involved in tau modification. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：247 / 249

页数：3

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