The emerging role of WISP proteins in tumorigenesis and cancer therapy

被引：35

作者：

Liu, Yi ^{[1
]}

Song, Yizuo ^{[1
]}

Ye, Miaomiao ^{[1
]}

Hu, Xiaoli ^{[1
]}

Wang, Z. Peter ^{[2
,3
,4
]}

Zhu, Xueqiong ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 2, Ctr Sci Res, Wenzhou 325027, Zhejiang, Peoples R China

[3] Bengbu Med Coll, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233030, Anhui, Peoples R China

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave, Boston, MA 02215 USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2019年 / 17卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Cancer; WISP; Oncogene; Drug; Targets; Therapy; HUMAN BREAST-CANCER; SQUAMOUS-CELL CARCINOMA; WNT/BETA-CATENIN PATHWAY; TISSUE GROWTH-FACTOR; CCN FAMILY; DIFFERENTIAL EXPRESSION; CANDIDATE GENES; MESSENGER-RNA; UP-REGULATION; CISPLATIN RESISTANCE;

D O I：

10.1186/s12967-019-1769-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.

引用

页数：14

共 101 条

[1] WNT signalling pathways as therapeutic targets in cancer [J].