Association between suppressors of cytokine signalling, T-helper type 1/T-helper type 2 balance and allergic sensitization in children

被引：21

作者：

Daegelmann, C. ^{[1
]}

Herberth, G. ^{[1
]}

Roeder, S.

Herbarth, O. ^{[4
]}

Giese, T. ^{[2
]}

Kraemer, U. ^{[3
]}

Behrendt, H. ^{[5
]}

Borte, M. ^{[6
,7
]}

Heinrich, J.

Emmrich, F. ^{[8
,9
]}

Lehmann, I. ^{[1
]}

机构：

[1] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, Helmholtz Ctr Environm Res, D-04318 Leipzig, Germany

[2] Univ Heidelberg, Inst Immunol, D-6900 Heidelberg, Germany

[3] IUF Inst Environm Med Res, Dusseldorf, Germany

[4] UFZ Helmholtz Ctr Environm Res, Dept Human Exposure Res & Epidemiol, Helmholtz Ctr Environm Res, D-04318 Leipzig, Germany

[5] Tech Univ Munich, ZAUM Ctr Allergy & Environm, Div Environm Dermatol & Allergy, GSF, D-8000 Munich, Germany

[6] Municipal Hosp St Georg, Childrens Hosp, Leipzig, Germany

[7] Univ Leipzig, Dept Pediat, Leipzig, Germany

[8] Inst Epidemiol, Natl Res Ctr Environm & Hlth, GSF, Neuherberg, Germany

[9] Univ Leipzig, Inst Clin Immunol & Transfus Med, Leipzig, Germany

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2008年 / 38卷 / 03期

关键词：

allergic sensitization; children; CIS; IgE; SOCS1; SOCS3; SOCS5; Th1/Th2;

D O I：

10.1111/j.1365-2222.2007.02913.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background Suppressors of cytokine signalling (SOCS) family members have been shown to play an important role in the balance of cytokines that determine the onset of T-helper type 1 (Th1)- and Th2-mediated immune responses. In particular, for cytokine-induced Src-homology 2 protein (CIS), SOCS1, SOCS3 and SOCS5, a role in the regulation of T cell differentiation has been discussed. However, only few data exist so far in the human system. Objectives The aim of the present study was to analyse the relationship between these suppressors and Th1/Th2 regulation as well as allergic sensitizations within a population-based study. Methods Within the Lifestyle-Immune system-Allergy plus cohort study, mRNA was prepared from blood samples of 6-year-old children for the analysis of cytokines, transcription factors for T cell regulation and SOCS molecule expression by quantitative real-time polymerase chain reaction. In addition, total and specific IgE concentrations have been measured by the Pharmacia CAP System. A complete data set from 248 children was available. Results Among the SOCS molecules investigated, only SOCS1 showed a strong positive correlation to allergic sensitizations. In addition, an up-regulated SOCS1 expression correlated with down-regulated T-box expressed in T cells (Tbet) and higher expression levels of GATA-binding protein 3 (GATA-3) and IL-4. No association between SOCS1 and forkhead box P3 (FOXP3) was observed. For SOCS3, SOCS5 and CIS, a contradictory picture was found. The expression of these SOCS molecules was positively correlated with Tbet and FOXP3 and (with the exception of CIS) negatively with IL-4. Conclusions Our data suggest that SOCS3, SOCS5 and CIS, which correlate with an up-regulated Th1 and regulatory T cell activity, are without relevance for the allergic status. In contrast, SOCS1 might be involved in the development of a Th2-skewed immune response and subsequent allergic sensitizations.

引用

页码：438 / 448

页数：11

共 40 条

[1] Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells [J].