Individual responses to novelty are associated with differences in behavioral and neurochemical profiles

被引:44
作者
Antoniou, K. [1 ,2 ]
Papathanasiou, G. [2 ]
Papalexi, E. [3 ]
Hyphantis, T. [4 ]
Nomikos, G. G. [5 ]
Spyraki, C. [2 ]
Papadopoulou-Daifoti, Z. [2 ]
机构
[1] Univ Ioannina, Dept Pharmacol, Sch Med, GR-45110 Ioannina, Greece
[2] Univ Athens, Sch Med, Dept Expt Pharmacol, Athens 11527, Greece
[3] Univ Athens, Sch Med, Dept Histol & Embryol, Athens 11527, Greece
[4] Univ Ioannina, Sch Med, Dept Psychiat, GR-45110 Ioannina, Greece
[5] Amgen Inc, Cambridge Res Ctr, Cambridge, MA 02139 USA
关键词
open-field activity; high responders; low responders; rats;
D O I
10.1016/j.bbr.2007.10.010
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Experimental animals can be differentiated on the basis of their horizontal or vertical activity to high responders (HR) and low responders (LR) upon exposure to a novel environment. These individual differences have been associated with behavioral and neurobiological differences in a number of experimental procedures used for studying sensitivity to psychostimulants, anxiety, depression, and cognitive function. In the present study. we differentiated the rats to FIR and LR based on their vertical activity upon exposure to a novel environment. Additionally, we ascertained whether HR and LR rats differ in a battery of tests such as passive avoidance (PA), object recognition (OR), and the water-maze (WM) that provide indices for cognitive function and the forced swim test (FST), an animal model of affective responsivity and antidepressant-like activity. Potential differences in neurochemical indices between the two phenotypes were also examined. HR rats displayed impaired non-spatial object recognition memory. but enhanced spatial performance. as compared to LR rats. FST induced "depressive-like" symptoms in both phenotypes that were differently manifested in HR versus LR rats. Neurochemical findings revealed distinct differences in serotonergic and dopaminergic activity in the striatum and the prefrontal cortex of HR as compared to LR rats. The above results show that HR and LR rats exhibit important differences in a battery of tests related to cognitive performance or affective responsivity, which may be associated with differences in certain neurobiological parameters. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:462 / 472
页数:11
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