Diastereo- and Enantioselective Synthesis of Oxazine and Oxazolidine Derivatives with a Chiral Quaternary Carbon Center under Multifunctional Catalysis

被引：41

作者：

Jin, Zhichao ^{[1
]}

Wang, Xiao ^{[1
]}

Huang, Huicai ^{[1
]}

Liang, Xinmiao ^{[1
]}

Ye, Jinxing ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ORGANOCATALYTIC MICHAEL ADDITION; HETEROCYCLES; OLEFIN; CONSTRUCTION; SOLVENT; ENONES;

D O I：

10.1021/ol102643a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An easy one-pot, multistep cascade reaction which could afford a series of substituted benzo[d]pyrido[2,1-b]oxazolidine and [1,3]oxazine derivatives in a highly enantio- (up to 98% ee) and diastereoselective (4:1 to >20:1 dr) manner with generally good to excellent yields (up to 99%) has been developed. This well designed strategy could be applied to a wide scope of substrates under mild conditions with simple operations.

引用

页码：564 / 567

页数：4

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