Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes

被引：31

作者：

Degner-Leisso, Stephanie C. ^{[1
]}

Feeney, Ann J. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

来源：

SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 06期

关键词：

Epigenetics; Immunoglobulin genes; Locus contraction; Histone post-translational modifications; V(D)J recombination; Repertoire; B-CELL DEVELOPMENT; V-H GENES; HEAVY-CHAIN GENE; DEVELOPMENTAL-STAGE; NONLYMPHOID CELLS; BINDING FACTOR; CTCF SITES; RECOMBINATION; RECEPTOR; LOCUS;

D O I：

10.1016/j.smim.2010.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

V(D)J recombination is a crucial component of the adaptive immune response, allowing for the production of a diverse antigen receptor repertoire (Ig and TCR). This review will focus on how epigenetic regulation and 3-dimensional (3D) interactions may control V(D)J recombination at Ig loci. The interplay between transcription factors and post-translational modifications at the Igh, IgK, and Ig lambda loci will be highlighted. Furthermore, we propose that the spatial organization and epigenetic boundaries of each Ig loci before and during V(D)J recombination may be influenced in part by the CTCF/cohesin complex. Taken together, the many epigenetic and 3D layers of control ensure that Ig loci are only rearranged at appropriate stages of B cell development. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：346 / 352

页数：7

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