Iridium-Catalyzed Single-Step N-Substituted Lactam Synthesis from Lactones and Amines

被引：34

作者：

Kim, Kicheol ^{[1
]}

Hong, Soon Hyeok ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Nat Sci, Dept Chem, Seoul 151747, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

ASTERISK-IR COMPLEX; ALKYLATION; ALCOHOLS; ACID; HETEROCYCLIZATION; LACTAMIZATION; CYCLIZATION; MECHANISM; OXIDATION; LIGANDS;

D O I：

10.1021/acs.joc.5b00101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic lactam synthesis was achieved directly from lactones and amines using an Ir catalyst. Three sequential transformations-aminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamide-afforded the corresponding N-substituted lactams.

引用

页码：4152 / 4156

页数：5

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