Baclofen overdose: A curious case of medical sales representative

被引：4

作者：

Gautam, Swotantra ^{[1
]}

Neupane, Aakash ^{[2
]}

Chamlagain, Mandita ^{[3
]}

Pokhrel, Sandip ^{[2
]}

Neupane, Durga ^{[2
]}

Acharya, Rochana ^{[2
]}

Panthi, Sagar ^{[2
]}

机构：

[1] Advent Hlth, Internal Med, PGY 1, Orlando, FL USA

[2] BP Koirala Inst Hlth Sci, Dharan 56700, Nepal

[3] Nidan Hosp, Lalitpur, Nepal

来源：

CLINICAL CASE REPORTS | 2022年 / 10卷 / 08期

关键词：

altered sensorium; baclofen; metabolic alkalosis; overdose; PRESCRIPTION DRUG-ABUSE; HEMODIALYSIS; EEG;

D O I：

10.1002/ccr3.6230

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this case report, a medical sales representative consumed 250 mg of Baclofen out of curiosity. Baclofen has life-threatening complications like seizures, respiratory depression, and coma. A majority of patients recover on symptomatic treatment. Baclofen has a great potential for abuse and overdose; therefore, its use must be strictly monitored.

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页数：4

相关论文

共 21 条

[1] PHARMACOKINETICS IN BACLOFEN OVERDOSE [J].

ANDERSON, P ;

NOHER, H ;

SWAHN, CG .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1984, 22 (01) :11-20

[2] Role of hemodialysis in baclofen overdose with normal renal function [J].

Dias, Lorraine S. ;

Vivek, G. ;

Manthappa, M. ;

Acharya, Raviraja V. .

INDIAN JOURNAL OF PHARMACOLOGY, 2011, 43 (06) :722-723

[3] EEG changes in intrathecal baclofen overdose: a case report and review of the literature [J].

Fakhoury, T ;

Abou-Khalil, B ;

Blumenkopf, B .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 107 (05) :339-342

[4] ATROPINE TREATMENT FOR BACLOFEN OVERDOSE [J].

FERNER, RE .

POSTGRADUATE MEDICAL JOURNAL, 1981, 57 (671) :580-581

[5] The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study [J].

Franklin, Teresa R. ;

Harper, Derek ;

Kampman, Kyle ;

Kildea-McCrea, Susan ;

Jens, Will ;

Lynch, Kevin G. ;

O'Brien, Charles P. ;

Childress, Anna Rose .

DRUG AND ALCOHOL DEPENDENCE, 2009, 103 (1-2) :30-36

[6]

Jameson J.L., 2018, Harrison's Principles of Internal Medicine, V20th ed.

[7] A Nationwide Register-Based Survey of Baclofen Toxicity [J].

Kiel, Louise Bendix ;

Hoegberg, Lotte Christine Groth ;

Jansen, Tejs ;

Petersen, John Asger ;

Dalhoff, Kim Peder .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2015, 116 (05) :452-456

[8] Prescription drug abuse rises globally [J].

Kuehn, Bridget M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 297 (12) :1306-1306

[9]

Leung Nicola Y, 2006, Emerg Med Australas, V18, P77, DOI 10.1111/j.1742-6723.2006.00805.x

[10] Prescription drug abuse up sharply in the USA [J].

McCarthy, Michael .

LANCET, 2007, 369 (9572) :1505-1506