Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa

被引：299
|
作者：
Tateda, K
Comte, R
Pechere, JC
Köhler, T
Yamaguchi, K
Van Delden, C
机构：
[1] Univ Geneva, Sch Med, Dept Genet & Microbiol, CH-1211 Geneva 14, Switzerland
[2] Toho Univ, Sch Med, Dept Microbiol, Tokyo 153, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期
关键词：
D O I：
10.1128/AAC.45.6.1930-1933.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report that 2 mug of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
引用
收藏
页码：1930 / 1933
页数：4
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