Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone

被引：124
作者：
Boveris, A
Cadenas, E
机构：
[1] Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90089 USA
[2] Univ Buenos Aires, Sch Pharm & Biochem, Dept Phys Chem, Buenos Aires, DF, Argentina
来源：
IUBMB LIFE | 2000年 / 50卷 / 4-5期
关键词：
apoptosis; hydrogen peroxide; mitochondria; nitric oxide; ubiquinone;
D O I：
10.1080/15216540051080912
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F-1-ATPase, The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.
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页码：245 / 250
页数：6
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