Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity

被引：33

作者：

Maixner, Nitzan ^{[1
]}

Bechor, Sapir ^{[1
,2
]}

Vershinin, Zlata ^{[2
,3
]}

Pecht, Tal ^{[1
,2
]}

Goldstein, Nir ^{[1
]}

Haim, Yulia ^{[1
]}

Rudich, Assaf ^{[1
,2
]}

机构：

[1] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Dept Microbiol & Immunol, IL-84105 Beer Sheva, Israel

来源：

PHYSIOLOGY | 2016年 / 31卷 / 04期

基金：

以色列科学基金会;

关键词：

INDUCED INSULIN-RESISTANCE; REGULATES AUTOPHAGY; ENHANCED AUTOPHAGY; LIPID-METABOLISM; KAPPA-B; INFLAMMATION; P53; ACTIVATION; ADIPOCYTES; RECEPTORS;

D O I：

10.1152/physiol.00048.2015

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.

引用

收藏

页码：270 / 282

页数：13

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