Role of gamma-delta (γδ) T cells in autoimmunity

被引：129
作者：
Paul, Sourav [1 ]
Shilpi [1 ]
Lal, Girdhari [1 ]
机构：
[1] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2015年 / 97卷 / 02期
关键词：
Th17; intraepithelial lymphocyte; inflammation; multiple sclerosis; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; COLLAGEN-INDUCED ARTHRITIS; INNATE LYMPHOID-CELLS; HUMAN-FETAL LIVER; PERIPHERAL-BLOOD; RETINOIC-ACID; HOST-DEFENSE; EFFECTOR FUNCTIONS; AIRWAY HYPERREACTIVITY; RECEPTOR EXPRESSION;
D O I：
10.1189/jlb.3RU0914-443R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
gamma delta T cells represent a small population of overall T lymphocytes (0.5-5%) and have variable tissue distribution in the body. gamma delta T cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of gamma delta T cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between gamma delta T cells and other immune cells and phenotypic and functional plasticity of gamma delta T cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of gamma delta T cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.
引用
收藏
页码：259 / 271
页数：13
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