Iron-Catalyzed Heterocycle and Arene Deprotonative Alkylation

被引：58
作者：
Tran, Ly Dieu [1 ]
Daugulis, Olafs [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 19期
关键词：
C-H BONDS; CARBON-HYDROGEN BONDS; CROSS-COUPLING REACTIONS; ARYL GRIGNARD-REAGENTS; DIRECT ARYLATION; FUNCTIONALIZED ARYL; HALIDES; PALLADIUM; ACTIVATION; QUINOLINES;
D O I：
10.1021/ol101684u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for iron-catalyzed deprotonative alkylation of arene C-H bonds by alkyl iodides and bromides has been developed. In the presence of an amide base, both primary and secondary alkyl halides can be coupled with furans, thiophenes, pyridine derivatives, and some electron-withdrawing-group containing arenes.
引用
收藏
页码：4277 / 4279
页数：3
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