Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents

被引：35

作者：

Olsen, David B. ^{[1
]}

Davies, Mary-Ellen

Handt, Larry ^{[2
]}

Koeplinger, Kenneth ^{[3
]}

Zhang, Nanyan Rena ^{[3
]}

Ludmerer, Steven W. ^{[1
]}

Graham, Donald ^{[1
]}

Liverton, Nigel ^{[4
]}

MacCoss, Malcolm ^{[4
]}

Hazuda, Daria ^{[1
]}

Carroll, Steven S. ^{[1
]}

机构：

[1] Merck Res Labs, Antiviral Res Dept, West Point, PA 19486 USA

[2] Merck Res Labs, Lab Anim Resources, West Point, PA 19486 USA

[3] Merck Res Labs, Dept Drug Metab & Pharmacokinet, West Point, PA 19486 USA

[4] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 02期

关键词：

INITIAL TREATMENT; PLUS RIBAVIRIN; INTERFERON-ALPHA-2B; REPLICATION; INHIBITOR; ANALOG;

D O I：

10.1128/AAC.00990-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection.

引用

页码：937 / 939

页数：3

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