Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

被引：77

作者：

Kathirvelan, D. ^{[1
]}

Haribabu, J. ^{[1
]}

Reddy, B. S. R. ^{[1
]}

Balachandran, C. ^{[2
]}

Duraipandiyan, V. ^{[2
]}

机构：

[1] CSIR, Cent Leather Res Inst, Ind Chem Lab, Madras 600020, Tamil Nadu, India

[2] Loyola Coll, Entomol Res Inst, Div Microbiol & Canc Biol, Madras 600034, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 02期

关键词：

Multicomponent reaction; Spirooxindole; Pyrazole moiety; Antimicrobial activity; Molecular docking; ENANTIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTION; DISCOVERY; SPIROOXINDOLES; POTENT; ISORHYNCHOPHYLLINE; RHYNCHOPHYLLINE; INHIBITORS; ALKALOIDS; LIBRARY;

D O I：

10.1016/j.bmcl.2014.10.099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study, a series of novel highly functionalized spiropyrrolidine-oxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl) acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：389 / 399

页数：11

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