Effect of storage on the stability of DL-PLA microspheres containing methadone

被引：7

作者：

Delgado, A ^{[1
]}

Evora, C ^{[1
]}

Llabrés, M ^{[1
]}

机构：

[1] Univ La Laguna, Fac Farm, Dept Ingn Quim & Tecnol Farmaceut, La Laguna 38200, Tenerife, Spain

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1998年 / 166卷 / 02期

关键词：

methadone; DL-PLA; microspheres; stability; degradation index; dissolution efficiency;

D O I：

10.1016/S0378-5173(98)00019-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work presents the changes in the characteristics of Dr-PLA microspheres of different polymer molecular weights and cll-methadone contents, prepared by the solvent evaporation method, after a 3-year storage at room temperature (20 +/- 2 degrees C) under desiccated conditions. Size, shape and loading did not change, while degradation index (DI) increased during storage independently of the methadone content. The most stable polymers were those of weight average molecular weight 63000 and 33000. The mechanism involved in the polymer degradation depending on the polymer molecular weight. The methadone release was evaluated through dissolution efficiency (DE). The DE variation with time was kept in the +/- 20% range. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 225

页数：3

共 10 条

[1] EFFECTS OF STORAGE ON THE PHYSICOCHEMICAL PROPERTIES AND RELEASE CHARACTERISTICS OF PROGESTERONE-LOADED POLY(L-LACTIDE) MICROSPHERES [J].

ASO, Y ;

YOSHIOKA, S ;

TERAO, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 93 (1-3) :153-159

[2] A PHYSICOCHEMICAL STUDY OF THE MORPHOLOGY OF PROGESTERONE-LOADED POLY (D,L-LACTIDE) MICROSPHERES [J].

BENOIT, JP ;

COURTEILLE, F ;

THIES, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 29 (2-3) :95-102

[3] A ONE-WEEK SUBDERMAL DELIVERY SYSTEM FOR L-METHADONE BASED ON BIODEGRADABLE MICROCAPSULES [J].

CHA, Y ;

PITT, CG .

JOURNAL OF CONTROLLED RELEASE, 1988, 7 (01) :69-78

[4] THE ACCELERATION OF DEGRADATION-CONTROLLED DRUG DELIVERY FROM POLYESTER MICROSPHERES [J].

CHA, Y ;

PITT, CG .

JOURNAL OF CONTROLLED RELEASE, 1989, 8 (03) :259-265

[5] Optimization of 7-day release (in vitro) from DL-PLA methadone microspheres [J].

Delgado, A ;

Evora, C ;

Llabres, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 134 (1-2) :203-211

[6] Degradation of DL-PLA-methadone microspheres during in vitro release [J].

Delgado, A ;

Evora, C ;

Llabres, M .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 140 (02) :219-227

[7] GENERAL MODEL FOR PREDICTION OF MOLECULAR-WEIGHT DISTRIBUTIONS OF DEGRADED POLYMERS - DEVELOPMENT AND COMPARISON WITH ULTRASONIC DEGRADATION EXPERIMENTS [J].

GLYNN, PAR ;

VANDERHO.BM ;

REILLY, PM .

JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, 1972, A 6 (08) :1653-1664

[8] MICROENCAPSULATION USING POLY(DL-LACTIC ACID) .4. EFFECT OF STORAGE ON THE MICROCAPSULE CHARACTERISTICS [J].

JALIL, R ;

NIXON, JR .

JOURNAL OF MICROENCAPSULATION, 1990, 7 (03) :375-383

[9] CONCEPT OF DISSOLUTION EFFICIENCY [J].

KHAN, KA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1975, 27 (01) :48-49

[10]

MAULDING H V, 1986, Journal of Controlled Release, V3, P103, DOI 10.1016/0168-3659(86)90071-4

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