Formal total synthesis of Palmerolide A

被引：10

作者：

Jena, Bighnanshu K. ^{[1
]}

Mohapatra, Debendra K. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2015年 / 71卷 / 34期

关键词：

Palmerolide A; Macrolide; Sharpless asymmetric dihydroxylation; Takai olefination; Ring-closing metathesis; RING-CLOSING METATHESIS; MARINE NATURAL-PRODUCT; SELECTIVE OXIDATION; SECONDARY ALCOHOLS; REVISED STRUCTURES; OLEFIN METATHESIS; A SYNTHESIS; FRAGMENT; RCM; ESTERIFICATION;

D O I：

10.1016/j.tet.2015.06.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective formal total synthesis of the 20-membered marine macrolide Palmerolide A, a highly potent antitumor agent, is described. The key steps involved in this synthesis are reductive elimination, Sharpless asymmetric dihydroxylation, protecting group dependent ring-closing metathesis reaction, Sharpless asymmetric epoxidation, Takai olefination and macrolactonization via Heck coupling reaction. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5678 / 5692

页数：15

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