Atroposelective synthesis of configurationally stable nonbiaryl N-C atropisomers through direct asymmetric aminations of 1,3-benzenediamines

被引：46

作者：

Wang, Donglei ^{[1
,2
]}

Jiang, Qianwen ^{[1
]}

Yang, Xiaoyu ^{[1
]}

机构：

[1] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 46期

关键词：

CATALYTIC ENANTIOSELECTIVE SYNTHESIS; NON-BIARYL ATROPISOMERS; STEREOSELECTIVE-SYNTHESIS; BRONSTED ACID; ANILIDES; BINOL; CONSTRUCTION; DERIVATIVES; ALLYLATION; ARYLATION;

D O I：

10.1039/d0cc02368j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly atroposelective synthesis of nonbiaryl N-C atropisomers was achievedviadirect aminations of 1,3-benzenediamines with azodicarboxylates enabled by chiral phosphoric acid catalysis. A series ofN-substituents, benzene-substituents and azodicarboxylates were well tolerated, generating N-C atropisomers with high configurational stability. The facile derivatizations and utilizations of the chiral products as novel chiral organocatalysts demonstrate the value of these reactions.

引用

页码：6201 / 6204

页数：4

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