Antioxidant and Anti-Inflammatory Effects of Scoparia dulcis L.

被引：16

作者：

Coulibaly, Ahmed Y. ^{[1
]}

Kiendrebeogo, Martin ^{[1
]}

Kehoe, Patrick G. ^{[3
,4
]}

Sombie, Pierre A. E. D. ^{[1
]}

Lamien, Charles E. ^{[1
,5
]}

Millogo, Jeanne F. ^{[2
]}

Nacoulma, Odile G. ^{[1
]}

机构：

[1] Univ Ouagadougou, Lab Biochem & Appl Chem Labioca, Training & Res Unit Life Sci & Earth Sci UFR SVT, Ouagadougou 09, Burkina Faso

[2] Univ Ouagadougou, Lab Biol & Plant Ecol, Training & Res Unit Life Sci & Earth Sci UFR SVT, Ouagadougou 09, Burkina Faso

[3] Univ Bristol, Dept Clin Sci N Bristol, Bristol, Avon, England

[4] Frenchay Hosp, Inst Clin Neurosci, Bristol BS16 1LE, Avon, England

[5] IAEA, Anim Prod Unit, FAO IAEA Agr & Biotechnol Lab, A-1400 Vienna, Austria

来源：

JOURNAL OF MEDICINAL FOOD | 2011年 / 14卷 / 12期

关键词：

anti-inflammatory; antioxidant; free radical; lipid peroxidation; lipoxygenase; polyphenols; Scoparia dulcis; xanthine oxidase; SCOPADULCIC ACID-B; LIPID-PEROXIDATION; IN-VITRO; INHIBITORY-ACTIVITY; OXIDATIVE STRESS; MEDICINAL-PLANTS; XANTHINE-OXIDASE; BETA-CAROTENE; TOTAL PHENOLS; EXTRACTS;

D O I：

10.1089/jmf.2010.0191

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different extracts were obtained from Scoparia dulcis L. (Scrophulariaceae) by successive extraction with hexane, chloroform, and methanol. These extracts exhibited significant antioxidant capacity in various antioxidant models mediated (xantine oxidase and lipoxygenase) or not mediated (2,2-diphenyl-picrylhydrazyl, ferric-reducing antioxidant power, beta-carotene bleaching, lipid peroxidation) by enzymes. The antioxidant activity of the extracts was related to their phytochemical composition in terms of polyphenol and carotenoid contents. The chloroform extract was richest in phytochemicals and had the highest antioxidant activity in the different antioxidant systems. All the extracts exhibited less than 50% inhibition on xanthine oxidase but more than 50% inhibition on lipid peroxidation and lipoxygenase. The extracts strongly inhibited lipid peroxidation mediated by lipoxygenase.

引用

页码：1576 / 1582

页数：7

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