Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex

被引：74

作者：

Trilles, Luciana ^{[1
]}

Meyer, Wieland ^{[2
]}

Wanke, Bodo ^{[1
]}

Guarro, Josep ^{[3
]}

Lazera, Marcia ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz FIOCRUZ, Mycol Lab, Inst Pesquisa Clin Evandro Chagas IPEC, BR-21040900 Rio De Janeiro, Brazil

[2] Univ Sydney, Westmead Hosp, Sydney Inst Emerging Infect Dis & Biosecur,Mol My, Sydney Med Sch Westmead,Westmead Millennium Inst, Westmead, NSW 2145, Australia

[3] Univ Rovira & Virgili, Fac Med & Ciencies Salut, IISPV, E-43201 Reus, Spain

来源：

MEDICAL MYCOLOGY | 2012年 / 50卷 / 03期

关键词：

Cryptococcus neoformans; Cryptococcus gattii; molecular types; antifungal susceptibility; IN-VITRO SUSCEPTIBILITIES; GENOTYPE;

D O I：

10.3109/13693786.2011.602126

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Members of the Cryptococcus neoformans/C. gattii species complex are grouped into eight molecular types, differing in their epidemiology, disease severity and geographic range. Recent in vitro antifungal susceptibility studies of isolates of the complex revealed contradictory results. The objective of the present study was to assess if this variation is random or correlates with different molecular types by testing the in vitro antifungal susceptibility of 18 C. neoformans (VNI), 11 C. gattii (VGI) and 38 C. gattii (VGII) strains from Brazil to eight antifungal drugs using the CLSI microdilution method. We herein report that the molecular type VGII is the least susceptible genotype, followed by VGI and VNI. This indicates a clear correlation between antifungal susceptibilities and genotypes of the causative cryptococcosis agents, emphasizing the importance of determining the molecular type as part of the clinical diagnostic process to enable an informed decision as to the most appropriate antifungal treatment.

引用

收藏

页码：328 / 332

页数：5

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