Bile Acid-Induced Cholemic Nephropathy

被引：50

作者：

Krones, Elisabeth ^{[1
]}

Wagner, Martin ^{[1
]}

Eller, Kathrin ^{[2
]}

Rosenkranz, Alexander R. ^{[2
]}

Trauner, Michael ^{[3
]}

Fickert, Peter ^{[1
]}

机构：

[1] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Res Unit Expt & Mol Hepatol, AT-8036 Graz, Austria

[2] Med Univ Graz, Clin Div Nephrol, Dept Internal Med, AT-8036 Graz, Austria

[3] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Hans Popper Lab Mol Hepatol, Vienna, Austria

来源：

DIGESTIVE DISEASES | 2015年 / 33卷 / 03期

基金：

奥地利科学基金会;

关键词：

Acute kidney injury; Cholemic nephropathy; Hepatorenal syndrome; GLOMERULAR-FILTRATION-RATE; ACUTE KIDNEY INJURY; SERUM CYSTATIN-C; IMPAIRED RENAL-FUNCTION; DUCT-LIGATED RATS; PROGRESSIVE TUBULOINTERSTITIAL NEPHROPATHY; ORTHOTOPIC LIVER-TRANSPLANTATION; ISCHEMIA-REPERFUSION INJURY; OBSTRUCTIVE-JAUNDICE; HEPATORENAL-SYNDROME;

D O I：

10.1159/000371689

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Kidney injury in deeply jaundiced patients became known as cholemic nephropathy. This umbrella term covers impaired renal function in cholestatic patients with characteristic histomorphological changes including intratubular cast formation and tubular epithelial cell injury. Cholemic nephropathy represents a widely underestimated but important cause of kidney dysfunction in patients with cholestasis and advanced liver disease. However, the nomenclature is inconsistent since there are numerous synonyms used; the underlying mechanisms of cholemic nephropathy are not entirely clear, and widely accepted diagnostic criteria are still missing. Consequently, the current article aims to summarize the present knowledge on the clinical and morphological characteristics, available preclinical models, derived potential pathomechanisms, and future diagnostic and therapeutic strategies in cholemic nephropathy. Furthermore, we provide a potential research agenda for this evolving field. (C) 2015 S. Karger AG, Basel

引用

页码：367 / 375

页数：9

共 91 条

[1] SURGICAL EXPERIENCE OF DEEPLY JAUNDICED PATIENTS WITH BILE-DUCT OBSTRUCTION [J].