The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism

被引：14
作者：
Ahsan, Mahdi [1 ]
Garneau, Lea [1 ,2 ]
Aguer, Celine [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada
[2] Inst Savoir Montfort Rech, Ottawa, ON, Canada
[3] McGill Univ, Fac Med & Hlth Sci, Dept Physiol, Campus Outaouais, Gatineau, PQ, Canada
[4] Univ Ottawa, Fac Hlth Sci, Sch Human Kinet, Ottawa, ON, Canada
[5] Univ Ottawa, Fac Hlth Sci, Interdisciplinary Sch Hlth Sci, Ottawa, ON, Canada
来源：
FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
myokines; AMPK; skeletal muscle; cell signalling; glucose metabolism; lipid metabolism; FATTY-ACID OXIDATION; FOLLISTATIN-LIKE PROTEIN-1; EXERCISE-INDUCED CYTOKINES; LEUKEMIA INHIBITORY FACTOR; INSULIN-RESISTANCE; GLYCOGEN-SYNTHASE; GLUCOSE-UPTAKE; NEUROTROPHIC FACTOR; ADIPOSE-TISSUE; METEORIN-LIKE;
D O I：
10.3389/fphys.2022.1040809
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.
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页数：23
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