Arachidonic acid metabolites in acute myocardial infarction

被引：35

作者：

Takase, B ^{[1
]}

Maruyama, T ^{[1
]}

Kurita, A ^{[1
]}

Uehata, A ^{[1
]}

Nishioka, T ^{[1
]}

Mizuno, K ^{[1
]}

Nakamura, H ^{[1
]}

Katsura, K ^{[1
]}

Kanda, Y ^{[1
]}

机构：

[1] NIPPON MED COLL,DEPT BIOCHEM 2,TOKYO,JAPAN

来源：

ANGIOLOGY | 1996年 / 47卷 / 07期

关键词：

D O I：

10.1177/000331979604700703

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Abnormalities of arachidonic acid metabolism are implicated in spasm and thrombosis in coronary arteries. Therefore, arachidonic acid metabolites were examined in patients with acute myocardial infarction (AMI). Plasma levels of thromboxane B-2 (TXB(2)), 6-ketoprostaglandin F-1 alpha (6KPGF(1 alpha)), leukotriene B-4 (LTB(4)), and slow reacting substance of anaphylaxis (SRS-A) composed of leukotriene C-4 (LTC(4)), leukotriene D-4 (LTD(4)) and leukotriene E(4) (LTE(4)), were measured in 19 AMI patients. Plasma levels of TXB(2), LTB(4), and SRS-A in systemic artery blood were significantly elevated during the acute stage (within twenty-four hours after the onset of chest pain) of AMI (TXB(2), 0.36 ng/mL; LTB(4), 0.75 ng/mL; and SRS-A [LTC(4)+LTD(4)+LTE(4)], 0.96 ng/mL) compared with those of normal controls (TXB(2), 0.18 ng/mL; LTB(4), 0.44 ng/mL; and SRS-A [LTC(4)+LTD(4)+LTE(4)], 0.31 ng/mL). These values decreased to near-normal control levels by one month after the AMI attack. The findings in this study suggest that abnormalities of arachidonic acid metabolism accompany, and may play a role in the pathogenesis of, AMI.

引用

页码：649 / 661

页数：13

共 44 条

[31] SYNTHESIS OF LIPOXYGENASE AND EPOXYGENASE PRODUCTS OF ARACHIDONIC-ACID BY NORMAL AND STENOSED CANINE CORONARY-ARTERIES [J].