XPA: A key scaffold for human nucleotide excision repair

被引：94
作者：
Sugitani, Norie
Sivley, Robert M.
Perry, Kelly E.
Capra, John A.
Chazin, Walter J. [1 ]
机构：
[1] Vanderbilt Univ, Struct Biol Ctr, 465 21st Ave,Suite 5140, Nashville, TN 37232 USA
来源：
DNA REPAIR | 2016年 / 44卷
基金：
美国国家卫生研究院;
关键词：
DNA repair; NER; XPA; Xeroderma pigmentosum; PIGMENTOSUM GROUP-A; DNA-BINDING DOMAIN; REPLICATION PROTEIN-A; COMPLEMENTATION GROUP-A; XERODERMA-PIGMENTOSUM; DAMAGED-DNA; CRYSTAL-STRUCTURE; TERMINAL DOMAIN; POLY(ADP-RIBOSE) POLYMERASE-1; STRUCTURAL BASIS;
D O I：
10.1016/j.dnarep.2016.05.018
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA. (C) 2016 Elsevier B.V. All rights reserved.
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收藏
页码：123 / 135
页数：13
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