Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study

被引：26

作者：

Buckley, Rachel F. ^{[1
,2
,3
,4
,5
]}

Sikkes, Sietske ^{[6
,7
,8
]}

Villemagne, Victor L. ^{[9
,10
]}

Mormino, Elizabeth C. ^{[11
]}

Rabin, Jennifer S. ^{[4
,12
]}

Burnham, Samantha ^{[13
]}

Papp, Kathryn V. ^{[3
,4
,5
]}

Dore, Vincent ^{[14
]}

Masters, Colin L.

Properzi, Michael J. ^{[4
]}

Schultz, Aaron P. ^{[3
,4
,5
]}

Johnson, Keith A. ^{[5
,15
]}

Rentz, Dorene M. ^{[3
,4
,5
]}

Sperling, Reisa A. ^{[3
,4
,5
]}

Amariglio, Rebecca E. ^{[3
,4
,5
]}

机构：

[1] Univ Melbourne, Florey Inst, Melbourne, Vic, Australia

[2] Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic, Australia

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Dept Neurol, Ctr Alzheimer Res & Treatment, 75 Francis St, Boston, MA 02115 USA

[6] Vrije Univ, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Alzheimer Ctr, Amsterdam, Netherlands

[7] Vrije Univ, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands

[8] Vrije Univ, Amsterdam Univ Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[9] Austin Hlth, Dept Nucl Med & Ctr PET, Melbourne, Vic, Australia

[10] Univ Melbourne, Austin Hlth, Dept Med, Melbourne, Vic, Australia

[11] Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA

[12] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[13] CSIRO Hlth & Biosecur, Australian eHlth Res Ctr, Melbourne, Vic, Australia

[14] CSIRO Hlth & Biosecur, Australian eHlth Res Ctr, Brisbane, Qld, Australia

[15] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Nucl Med & Mol Imaging, Boston, MA 02115 USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2019年 / 11卷 / 01期

基金：

加拿大健康研究院; 美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

Subjective cognitive decline; Amyloid; APOE epsilon 4; Alzheimer's disease; CEREBROSPINAL-FLUID BIOMARKERS; OLDER-ADULTS; MEMORY COMPLAINTS; APOE EPSILON-4; EVERYDAY COGNITION; BETA; DEMENTIA; BURDEN; RISK; SEX;

D O I：

10.1016/j.dadm.2019.08.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We aimed to examine the contribution of subjective cognitive decline (SCD) to reduce the number of beta-amyloid (A beta) positron emission tomography scans required for recruiting A beta+ clinically normal individuals in clinical trials. Methods: Three independent cohorts (890 clinically normal: 72 yrs 6.7; Female: 43.4%; SCD+: 24%; apolipoprotein E [APOE] epsilon 4+: 28.5%; A beta+: 32%) were used. SCD was dichotomized from one question. Using logistic regression, we classified A beta+ using the SCD dichotomy, APOE epsilon 4, sex, and age. Results: SCD increased odds of A beta+ by 1.58 relative to non-SCD. Female APOE epsilon 4 carriers with SCD exhibited higher odds of A beta+ (OR = 3.34), whereas male carriers with SCD showed a weaker, opposing effect (OR = 0.37). SCD endorsement reduces the number of A beta positron emission tomography scans to recruit A beta+ individuals by 13% and by 9% if APOE epsilon 4 status is known. Conclusion: SCD helps to classify those with high A beta, even beyond the substantial effect of APOE genotype. Collecting SCD is a feasible method for targeting recruitment for those likely on the AD trajectory. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：670 / 678

页数：9

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